5-Fluorouracil drug delivery system based on bacterial nanocellulose for colorectal cancer treatment: Mathematical and in vitro evaluation

E. Martínez, M. Osorio, C. Finkielstein, I. Ortíz, Maria S. Peresin, C. Castro

    Research output: Contribution to journalArticlepeer-review

    2 Scopus citations

    Abstract

    Colorectal cancer (CRC) is the third most common worldwide. Its treatment includes adjuvant chemotherapy with 5-fluorouracil (5FU) administered intravenously. 5FU is an antineoplastic drug of the fluoropyrimidines group, widely used in the treatment of solid tumors, mainly CRC. Nevertheless, it causes several adverse effects and poor effectiveness due to its short half-life. This work aimed to employ bacterial nanocellulose (BNC) as an encapsulation material for the oral administration of 5FU. First, the adsorption phenomena were analyzed by isotherms, thermodynamic parameters, and kinetic models. Then, encapsulation was carried out using spray-drying, and encapsulated 5FU desorption profiles were assessed in simulated fluids. The biological behavior was evaluated on colon cancer SW480 and SW620 cell lines. As result, it was found that at 25 °C a monolayer of 5FU was formed and the process showed to be the most spontaneous one. In the characterization of the nanocapsules, important changes were detected by the presence of 5FU. The delivery in the colon corresponded to a controlled release behavior. The in vitro assay indicated an improvement in the toxicity effect of the drug and its mechanism of action. Accordingly, BNC is a promising biomaterial for the development of a colon drug delivery platform of 5FU.

    Original languageEnglish
    Pages (from-to)802-815
    Number of pages14
    JournalInternational Journal of Biological Macromolecules
    Volume220
    DOIs
    StatePublished - 1 Nov 2022

    Bibliographical note

    Funding Information:
    The work has been funded by MINCIENCIAS , MINEDUCACIÓN , MINCIT and ICETEX , through the Program Ecosistema Científico Cod. FP44842-211-2018 Project number 58674 .

    Funding Information:
    The work has been funded by MINCIENCIAS, MINEDUCACIÓN, MINCIT and ICETEX, through the Program Ecosistema Científico Cod. FP44842-211-2018 Project number 58674.

    Publisher Copyright:
    © 2022

    Keywords

    • 5-Fluorouracil
    • Bacterial nanocellulose
    • Colorectal cancer
    • Cytotoxicity effect
    • Drug delivery system
    • Spray-drying

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