Agar de capa delgada: Una opción costoefectiva para el diagnóstico rápido de tuberculosis multirresistente

Translated title of the contribution: Thin layer agar represents a cost-effective alternative for the rapid diagnosis of multi-drug resistant tuberculosis

José M. Hernández-Sarmiento, Milton A. Martínez-Negrete, Diana M. Castrillón-Velilla, Sergio A. Mejía-Espinosa, Gloria I. Mejía-Mesa, Elsa M. Zapata-Fernández, Sara Rojas-Jiménez, Andrés E. Marín-Castro, Jaime A. Robledo-Restrepo

    Research output: Contribution to journalArticlepeer-review

    4 Scopus citations

    Abstract

    Objective Using cost-benefit analysis for comparing the thin-layer agar culture method to the standard multiple proportion method used in diagnosing multidrugresistant tuberculosis (MDR TB). Methods A cost-benefit evaluation of two diagnostic tests was made at the Corporación para Investigaciones Biológicas (CIB) in Medellín, Colombia. Results 100 patients were evaluated; 10.8 % rifampicin resistance and 14.3 % isoniazid resistance were found. A computer-based decision tree model was used for cost-effectiveness analysis (Treeage Pro); the thin-layer agar culture method was most cost-effective, having 100 % sensitivity, specificity and predictive values for detecting rifampicin and isoniazid resistance. The multiple proportion method value was calculated as being US$ 71 having an average 49 day report time compared to US$ 18 and 14 days for the thin-layer agar culture method. Discussion New technologies have been developed for diagnosing tuberculosis which are apparently faster and more effective; their operating characteristics must be evaluated as must their effectiveness in terms of cost-benefit. The present study established that using thin-layer agar culture was cheaper, equally effective and could provide results more quickly than the traditional method. This implies that a patient could receive MDR TB treatment more quickly.

    Translated title of the contributionThin layer agar represents a cost-effective alternative for the rapid diagnosis of multi-drug resistant tuberculosis
    Original languageSpanish
    Pages (from-to)101-113
    Number of pages13
    JournalRevista de Salud Publica
    Volume16
    Issue number1
    DOIs
    StatePublished - 1 Jan 2014

    Bibliographical note

    Publisher Copyright:
    © 2014, Universidad Nacional de Colombia. All rights reserved.

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