Assessment of Bacterial Nanocellulose Loaded with Acetylsalicylic Acid or Povidone-Iodine as Bioactive Dressings for Skin and Soft Tissue Infections

Shaydier Argel, Melissa Castaño, Daiver Estiven Jimenez, Sebastian Rodríguez, Maria Jose Vallejo, Cristina Isabel Castro, Marlon Andres Osorio

    Research output: Contribution to journalArticle in an indexed scientific journalpeer-review

    5 Scopus citations

    Abstract

    Bacterial nanocellulose (BNC) is a novel nanomaterial known for its large surface area, biocompatibility, and non-toxicity. BNC contributes to regenerative processes in the skin but lacks antimicrobial and anti-inflammatory properties. Herein, the development of bioactive wound dressings by loading antibacterial povidone-iodine (PVI) or anti-inflammatory acetylsalicylic acid (ASA) into bacterial cellulose is presented. BNC is produced using Hestrin–Schramm culture media and loaded via immersion in PVI and ASA. Through scanning electron microscopy, BNC reveals open porosity where the bioactive compounds are loaded; the mechanical tests show that the dressing prevents mechanical wear. The loading kinetic and release assays (using the Franz cell method) under simulated fluids present a maximum loading of 589.36 mg PVI/g BNC and 38.61 mg ASA/g BNC, and both systems present a slow release profile at 24 h. Through histology, the complete diffusion of the bioactive compounds is observed across the layers of porcine skin. Finally, in the antimicrobial experiment, BNC/PVI produced an inhibition halo for Gram-positive and Gram-negative bacteria, confirming the antibacterial activity. Meanwhile, the protein denaturation test shows effective anti-inflammatory activity in BNC/ASA dressings. Accordingly, BNC is a suitable platform for the development of bioactive wound dressings, particularly those with antibacterial and anti-inflammatory properties.

    Original languageEnglish
    Article number1661
    JournalPharmaceutics
    Volume14
    Issue number8
    DOIs
    StatePublished - Aug 2022

    Bibliographical note

    Publisher Copyright:
    © 2022 by the authors.

    Keywords

    • acetylsalicylic acid
    • bacterial nanocellulose
    • povidone-iodine
    • wound dressing

    Types Minciencias

    • Artículos de investigación con calidad A1 / Q1

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