Azopolymer based nanoparticles for phototriggered drug delivery

Sandra Perez-Buitrago; Pedro Mena-Giraldo; Rodolfo Pinal; Lina Hoyos-Palacio

doi:10.1109/EMBC.2019.8856432

Azopolymer based nanoparticles for phototriggered drug delivery

Sandra Perez-Buitrago
, Pedro Mena-Giraldo
, Rodolfo Pinal
, Lina Hoyos-Palacio

Research output: Chapter in Book/Conference proceeding › Conference and proceedings › peer-review

7 Scopus citations

Abstract

Controlled release by stimulus-responsive nanoparticles is oriented to increase the specificity of drug delivery, to improve the therapy effectiveness and minimizing side effects. This work presents the synthesis of photosensitive-polymeric nanoparticles as a potential system for localized drug delivery. First, the photoisomerizable amphiphilic-copolymer poly2-[4-phenylazophenoxy]ethyl acrylate-co-acrylic acid (PPAPE), was synthesized. Then, PPAPE was employed to prepare micellar nanoparticles by the nanoprecipitation method. Characterizations of the polymer were performed by proton nuclear magnetic resonance, X-ray photoelectron spectroscopy and FTIR spectroscopy. The morphology of the nanoparticles was analyzed by dynamic light scattering and transmission electron microscopy. Also, photostimulation response was confirmed by UV-VIS spectroscopy. Results indicate that the obtained photoresponsive nanoparticles have the size and photoisomerization necessary to perform the specific release of drugs.

Original language	English
Title of host publication	2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	1089-1092
Number of pages	4
ISBN (Electronic)	9781538613115
DOIs	https://doi.org/10.1109/EMBC.2019.8856432
State	Published - Jul 2019
Event	41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019 - Berlin, Germany Duration: 23 Jul 2019 → 27 Jul 2019

Publication series

Name	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)	1557-170X

Conference

Conference	41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019
Country/Territory	Germany
City	Berlin
Period	23/07/19 → 27/07/19

Bibliographical note

Publisher Copyright:
© 2019 IEEE.

Types Minciencias

Scientific events with a public engagement component

Access to Document

10.1109/EMBC.2019.8856432

Cite this

Perez-Buitrago, S., Mena-Giraldo, P., Pinal, R., & Hoyos-Palacio, L. (2019). Azopolymer based nanoparticles for phototriggered drug delivery. In 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019 (pp. 1089-1092). Article 8856432 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2019.8856432

Perez-Buitrago, Sandra ; Mena-Giraldo, Pedro ; Pinal, Rodolfo et al. / Azopolymer based nanoparticles for phototriggered drug delivery. 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019. Institute of Electrical and Electronics Engineers Inc., 2019. pp. 1089-1092 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

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title = "Azopolymer based nanoparticles for phototriggered drug delivery",

abstract = "Controlled release by stimulus-responsive nanoparticles is oriented to increase the specificity of drug delivery, to improve the therapy effectiveness and minimizing side effects. This work presents the synthesis of photosensitive-polymeric nanoparticles as a potential system for localized drug delivery. First, the photoisomerizable amphiphilic-copolymer poly2-[4-phenylazophenoxy]ethyl acrylate-co-acrylic acid (PPAPE), was synthesized. Then, PPAPE was employed to prepare micellar nanoparticles by the nanoprecipitation method. Characterizations of the polymer were performed by proton nuclear magnetic resonance, X-ray photoelectron spectroscopy and FTIR spectroscopy. The morphology of the nanoparticles was analyzed by dynamic light scattering and transmission electron microscopy. Also, photostimulation response was confirmed by UV-VIS spectroscopy. Results indicate that the obtained photoresponsive nanoparticles have the size and photoisomerization necessary to perform the specific release of drugs.",

author = "Sandra Perez-Buitrago and Pedro Mena-Giraldo and Rodolfo Pinal and Lina Hoyos-Palacio",

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doi = "10.1109/EMBC.2019.8856432",

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series = "Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS",

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Perez-Buitrago, S, Mena-Giraldo, P, Pinal, R & Hoyos-Palacio, L 2019, Azopolymer based nanoparticles for phototriggered drug delivery. in 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019., 8856432, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, Institute of Electrical and Electronics Engineers Inc., pp. 1089-1092, 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019, Berlin, Germany, 23/07/19. https://doi.org/10.1109/EMBC.2019.8856432

Azopolymer based nanoparticles for phototriggered drug delivery. / Perez-Buitrago, Sandra; Mena-Giraldo, Pedro; Pinal, Rodolfo et al.
2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019. Institute of Electrical and Electronics Engineers Inc., 2019. p. 1089-1092 8856432 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

Research output: Chapter in Book/Conference proceeding › Conference and proceedings › peer-review

TY - GEN

T1 - Azopolymer based nanoparticles for phototriggered drug delivery

AU - Perez-Buitrago, Sandra

AU - Mena-Giraldo, Pedro

AU - Pinal, Rodolfo

AU - Hoyos-Palacio, Lina

PY - 2019/7

Y1 - 2019/7

N2 - Controlled release by stimulus-responsive nanoparticles is oriented to increase the specificity of drug delivery, to improve the therapy effectiveness and minimizing side effects. This work presents the synthesis of photosensitive-polymeric nanoparticles as a potential system for localized drug delivery. First, the photoisomerizable amphiphilic-copolymer poly2-[4-phenylazophenoxy]ethyl acrylate-co-acrylic acid (PPAPE), was synthesized. Then, PPAPE was employed to prepare micellar nanoparticles by the nanoprecipitation method. Characterizations of the polymer were performed by proton nuclear magnetic resonance, X-ray photoelectron spectroscopy and FTIR spectroscopy. The morphology of the nanoparticles was analyzed by dynamic light scattering and transmission electron microscopy. Also, photostimulation response was confirmed by UV-VIS spectroscopy. Results indicate that the obtained photoresponsive nanoparticles have the size and photoisomerization necessary to perform the specific release of drugs.

AB - Controlled release by stimulus-responsive nanoparticles is oriented to increase the specificity of drug delivery, to improve the therapy effectiveness and minimizing side effects. This work presents the synthesis of photosensitive-polymeric nanoparticles as a potential system for localized drug delivery. First, the photoisomerizable amphiphilic-copolymer poly2-[4-phenylazophenoxy]ethyl acrylate-co-acrylic acid (PPAPE), was synthesized. Then, PPAPE was employed to prepare micellar nanoparticles by the nanoprecipitation method. Characterizations of the polymer were performed by proton nuclear magnetic resonance, X-ray photoelectron spectroscopy and FTIR spectroscopy. The morphology of the nanoparticles was analyzed by dynamic light scattering and transmission electron microscopy. Also, photostimulation response was confirmed by UV-VIS spectroscopy. Results indicate that the obtained photoresponsive nanoparticles have the size and photoisomerization necessary to perform the specific release of drugs.

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ER -

Perez-Buitrago S, Mena-Giraldo P, Pinal R, Hoyos-Palacio L. Azopolymer based nanoparticles for phototriggered drug delivery. In 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019. Institute of Electrical and Electronics Engineers Inc. 2019. p. 1089-1092. 8856432. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). doi: 10.1109/EMBC.2019.8856432

Azopolymer based nanoparticles for phototriggered drug delivery

Abstract

Publication series

Conference

Bibliographical note

Types Minciencias

Access to Document

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Cite this