Bioactive 3D-Shaped Wound Dressings Synthesized from Bacterial Cellulose: Effect on Cell Adhesion of Polyvinyl Alcohol Integrated In Situ

Marlon Osorio, Jorge Velásquez-Cock, Luz Marina Restrepo, Robín Zuluaga, Piedad Gañán, Orlando J. Rojas, Isabel Ortiz-Trujillo, Cristina Castro

Research output: Contribution to journalArticle in an indexed scientific journalpeer-review

23 Scopus citations

Abstract

We investigated wound dressing composites comprising fibrils of bacterial cellulose (BC) grown by fermentation in the presence of polyvinyl alcohol (PVA) followed by physical crosslinking. The reference biointerface, neat BC, favoured adhesion of fibroblasts owing to size exclusion effects. Furthermore, it resisted migration across the biomaterial. Such effects were minimized in the case of PVA/BC membranes. Therefore, the latter are suggested in cases where cell adhesion is to be avoided, for instance, in the design of interactive wound dressings with facile exudate control. The bioactivity and other properties of the membranes were related to their morphology and structure and considered those of collagen fibres. Bioactive materials were produced by simple 3D templating of BC during growth and proposed for burn and skin ulcer treatment.

Original languageEnglish
Article number3728485
JournalInternational Journal of Polymer Science
Volume2017
DOIs
StatePublished - 2017

Bibliographical note

Publisher Copyright:
© 2017 Marlon Osorio et al.

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