TY - JOUR
T1 - Bioactive 3D-Shaped Wound Dressings Synthesized from Bacterial Cellulose
T2 - Effect on Cell Adhesion of Polyvinyl Alcohol Integrated In Situ
AU - Osorio, Marlon
AU - Velásquez-Cock, Jorge
AU - Restrepo, Luz Marina
AU - Zuluaga, Robín
AU - Gañán, Piedad
AU - Rojas, Orlando J.
AU - Ortiz-Trujillo, Isabel
AU - Castro, Cristina
N1 - Publisher Copyright:
© 2017 Marlon Osorio et al.
PY - 2017
Y1 - 2017
N2 - We investigated wound dressing composites comprising fibrils of bacterial cellulose (BC) grown by fermentation in the presence of polyvinyl alcohol (PVA) followed by physical crosslinking. The reference biointerface, neat BC, favoured adhesion of fibroblasts owing to size exclusion effects. Furthermore, it resisted migration across the biomaterial. Such effects were minimized in the case of PVA/BC membranes. Therefore, the latter are suggested in cases where cell adhesion is to be avoided, for instance, in the design of interactive wound dressings with facile exudate control. The bioactivity and other properties of the membranes were related to their morphology and structure and considered those of collagen fibres. Bioactive materials were produced by simple 3D templating of BC during growth and proposed for burn and skin ulcer treatment.
AB - We investigated wound dressing composites comprising fibrils of bacterial cellulose (BC) grown by fermentation in the presence of polyvinyl alcohol (PVA) followed by physical crosslinking. The reference biointerface, neat BC, favoured adhesion of fibroblasts owing to size exclusion effects. Furthermore, it resisted migration across the biomaterial. Such effects were minimized in the case of PVA/BC membranes. Therefore, the latter are suggested in cases where cell adhesion is to be avoided, for instance, in the design of interactive wound dressings with facile exudate control. The bioactivity and other properties of the membranes were related to their morphology and structure and considered those of collagen fibres. Bioactive materials were produced by simple 3D templating of BC during growth and proposed for burn and skin ulcer treatment.
UR - http://www.scopus.com/inward/record.url?scp=85030764058&partnerID=8YFLogxK
U2 - 10.1155/2017/3728485
DO - 10.1155/2017/3728485
M3 - Artículo
AN - SCOPUS:85030764058
VL - 2017
JO - International Journal of Polymer Science
JF - International Journal of Polymer Science
SN - 1687-9422
M1 - 3728485
ER -