Bioactive 3D-Shaped Wound Dressings Synthesized from Bacterial Cellulose: Effect on Cell Adhesion of Polyvinyl Alcohol Integrated In Situ

Marlon Osorio, Jorge Velásquez-Cock, Luz Marina Restrepo, Robín Zuluaga, Piedad Gañán, Orlando J. Rojas, Isabel Ortiz-Trujillo, Cristina Castro

    Research output: Contribution to journalArticlepeer-review

    17 Scopus citations

    Abstract

    We investigated wound dressing composites comprising fibrils of bacterial cellulose (BC) grown by fermentation in the presence of polyvinyl alcohol (PVA) followed by physical crosslinking. The reference biointerface, neat BC, favoured adhesion of fibroblasts owing to size exclusion effects. Furthermore, it resisted migration across the biomaterial. Such effects were minimized in the case of PVA/BC membranes. Therefore, the latter are suggested in cases where cell adhesion is to be avoided, for instance, in the design of interactive wound dressings with facile exudate control. The bioactivity and other properties of the membranes were related to their morphology and structure and considered those of collagen fibres. Bioactive materials were produced by simple 3D templating of BC during growth and proposed for burn and skin ulcer treatment.

    Original languageEnglish
    Article number3728485
    JournalInternational Journal of Polymer Science
    Volume2017
    DOIs
    StatePublished - 2017

    Bibliographical note

    Publisher Copyright:
    © 2017 Marlon Osorio et al.

    Fingerprint

    Dive into the research topics of 'Bioactive 3D-Shaped Wound Dressings Synthesized from Bacterial Cellulose: Effect on Cell Adhesion of Polyvinyl Alcohol Integrated In Situ'. Together they form a unique fingerprint.

    Cite this