TY - JOUR
T1 - Células T CAR
T2 - Car T cells: Progress that passes the advances in the treatment of malignant hemopathies
AU - Martínez-Sánchez, Lina María
AU - Álvarez-Hernández, Luis Felipe
AU - Roldán-Isaza, Mariana
N1 - Publisher Copyright:
© 2018, Editorial Ciencias Medicas. All rights reserved.
PY - 2018/10/1
Y1 - 2018/10/1
N2 - Introduction: CAR T cells (antigenic chimeric receptor) are a new type of emergent treatment classified among adoptive cell transfer immunotherapies (ACT). This receptor will contribute to the detection of specific malignant antigens on the membrane of cancer cells and the destruction of these, which together with chemotherapy, allow an effective anti-tumor treatment. Objective: to review the new therapies with CAR T cells in the common lymphomas, besides exposing the main complications and new therapeutic uses . Methods: an exhaustive bibliographic review was carried out from December 2018 to June 2018 in databases such as Medline, Science Direct, Lilacs and Embase, with the search MeSH terms: lymphoma, immunotherapy, genetic engineering, T lymphocytes. Conclusion: there are numerous applications of which this type of immunotherapy is a participant, currently proposes a therapeutic revolution in which not only include hematological malignancies, but also in solid tumors, is undoubtedly a feat of genetic engineering and medicine
AB - Introduction: CAR T cells (antigenic chimeric receptor) are a new type of emergent treatment classified among adoptive cell transfer immunotherapies (ACT). This receptor will contribute to the detection of specific malignant antigens on the membrane of cancer cells and the destruction of these, which together with chemotherapy, allow an effective anti-tumor treatment. Objective: to review the new therapies with CAR T cells in the common lymphomas, besides exposing the main complications and new therapeutic uses . Methods: an exhaustive bibliographic review was carried out from December 2018 to June 2018 in databases such as Medline, Science Direct, Lilacs and Embase, with the search MeSH terms: lymphoma, immunotherapy, genetic engineering, T lymphocytes. Conclusion: there are numerous applications of which this type of immunotherapy is a participant, currently proposes a therapeutic revolution in which not only include hematological malignancies, but also in solid tumors, is undoubtedly a feat of genetic engineering and medicine
KW - CAR T
KW - Genetic engineering
KW - Immunotherapy
KW - Lymphoma
KW - T-lymphocytes
UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85067114533&origin=resultslist&sort=plf-f&src=s&sid=f4e4a97b56fb5881a21c31c40b9b9e0d&sot=b&sdt=b&s=TITLE-ABS-KEY%28C%C3%A9lulas+T+CAR%3A+proeza+que+traspasa+los+avances+en+el+tratamiento+de+las+hemopat%C3%ADas+malignas%29&sl=87&sessionSearchId=f4e4a97b56fb5881a21c31c40b9b9e0d
M3 - Artículo de revisión
AN - SCOPUS:85067114533
SN - 0864-0289
VL - 34
SP - 41
EP - 50
JO - Revista Cubana de Hematologia, Inmunologia y Hemoterapia
JF - Revista Cubana de Hematologia, Inmunologia y Hemoterapia
IS - 4
ER -
