Caracterización clínica y dermatoscópica de los pacientes con diagnóstico de síndrome de uña frágil no secundario a enfermedades dermatológicas

Objective: To describe the clinical and dermatoscopical characteristics of patients with a diagnosis of nail fragility syndrome (NFS) not secondary to dermatological disease in two specialized Colombian centers. Material and methods: Cross sectional descriptive study. Patients older than 18 years with NFS who were evaluated at either in Clinica Universitaria Bolivariana dermatology service or a private practice dermatology center ranging from October 2015 to February 2017 were prospectively enrolled. Demographic data, comorbidities, signs, symptoms, clinical and dermatoscopic examination of four nails were evaluated and the presence or absence of affectation in the toenails was determined as well. The perception of quality of life was inquired. Results: 62 patients and 248 nails with NFS in the hands were evaluated; 91.9% were women and the median age was 53 years (RIQ: 31-61). At least one comorbidity was reported in 20.9%. The reported ungular symptoms were 96.8% rupture, 93.5% weak nails, 67.7% lack of growth and 25.8% pain; 67.7% of patients perceived impairment of quality of life and median duration of symptoms was 12 months (RIQ: 6-24); 22.6% reported toenail involvement. Clinical signs and dermatoscopic findings were respectively: 76.2-84.7% onicorrexis, 64.9-79.8% onychosis, 9.7-10.1% lateral border rupture and 5.2-8.5% longitudinal divisions.