Computational Simulation of Franz Diffusion Cell Method for Bacterial Nanocellulose Wound Dressings

Shaydier Argel Pérez, Daiver Estiven Jiménez Gutiérrez, Alexander León Ramírez, Samuel Villa Alvarez, Marlon Andres Osorio Delgado, Isabel Cristina Castro Herazo, Gustavo Suárez Guerrero

    Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

    Abstract

    In this paper, computational simulations were used to analyze the thermo-electro-diffusive behavior of the povidone-iodine (PVI) and the acetylsalicylic acid (ASA) embed in a nanocellulose wound dressing. Mathematical models were determined with Fourier’s law for the thermal model, Maxwell’s equations for the electric phenomena and Fick’s law to model the diffusive behavior to simulate the Franz cell (FC) method. Also, 6 computational models were built to determine effectivity of the FC method in the skin, considering flux conditions for the drug delivery, temperature, and electric conditions. For this models, numerical reticules were designed for the implementation of algorithms using MATLAB and the mathematical equations were solved using Finite Difference Method (FDM). The results showed an appropriate behavior of the diffusive process, were the diffusion of PVI and ASA through epidermis was observed, also in the electric simulation it was observed that the current travel only through the primary layers of the skin; moreover, after the simulation of two thermic processes: heating plate and water bath, the latter proved to be the method that could be more appropriate for applying heat in Franz cells. The results obtained in this paper can provide predictions that could guide future in vitro experimental tests in a more assertive way, also it will allow predicting the behavior of the release of drugs from wound dressings. Also, the algorithms used, and computational tests were a powerful tool that contributes to a more assertive experimental methodology.

    Original languageEnglish
    Title of host publicationApplied Computer Sciences in Engineering - 7th Workshop on Engineering Applications, WEA 2020, Proceedings
    EditorsJuan Carlos Figueroa-García, Fabián Steven Garay-Rairán, Germán Jairo Hernández-Pérez, Yesid Díaz-Gutierrez
    PublisherSpringer Science and Business Media Deutschland GmbH
    Pages387-397
    Number of pages11
    ISBN (Print)9783030618339
    DOIs
    StatePublished - 2020
    Event7th Workshop on Engineering Applications, WEA 2020 - Bogota, Colombia
    Duration: 7 Oct 20209 Oct 2020

    Publication series

    NameCommunications in Computer and Information Science
    Volume1274 CCIS
    ISSN (Print)1865-0929
    ISSN (Electronic)1865-0937

    Conference

    Conference7th Workshop on Engineering Applications, WEA 2020
    Country/TerritoryColombia
    CityBogota
    Period7/10/209/10/20

    Bibliographical note

    Publisher Copyright:
    © 2020, Springer Nature Switzerland AG.

    Keywords

    • Computational simulation
    • Franz diffusion cell
    • Matlab
    • Wound dressings

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