Delusions and Hallucinations Are Associated With Greater Severity of Delirium

Paula T. Trzepacz, José G. Franco, David Meagher, Yasuhiro Kishi, Esteban Sepúlveda, Ana M. Gaviria, Chun Hsin Chen, Ming Chyi Huang, Leticia M. Furlanetto, Daniel Negreiros, Yanghyun Lee, Jeong Lan Kim, Jacob Kean

Research output: Contribution to journalArticle in an indexed scientific journalpeer-review

2 Scopus citations


Background: The 3 core domains of delirium (cognitive, higher level thinking, circadian) do not include the less common noncore psychotic symptoms. However, psychosis might inform about perturbations of neural circuitry, outcomes, or suggest tailored clinical management. Objective: We assessed relationships between psychosis and other characteristics of delirium in patients without dementia or antipsychotics treatment. Methods: Cross-sectional analysis of 366 adults with delirium per the Delirium Rating Scale Revised-98, whose items distinguish hallucinations and delusions from other types of misperceptions and abnormal thought content, assessed during the preceding 24 hours to capture symptom severity fluctuation. The relationship of psychosis with other delirium characteristics was assessed using bivariate comparisons and analysis of variance as appropriate for groups with no psychosis and any psychosis (hallucinations and/or delusions), and subgroups with only hallucinations, only delusions, or both. A discriminant logistic model assessed variables associated with presence of any psychotic features versus none. Results: Delirium with any psychotic features occurred in 44.5% (163 of 366). Of the 366, 119 (32.5%) had only hallucinations (Hall), 14 (3.8%) had only delusions (Del), and 30 (8.2%) had both (Both). In the psychotic group (n = 163), 73.0% were Hall, 8.6% Del, and 18.4% Both. All psychotic patient groupings had significantly greater delirium severity on the Delirium Rating Scale Revised-98. Delusions and hallucinations were discordant for occurring together. The discriminant model found increased odds of having psychosis as 3 symptom severities increased (visuospatial ability, thought process, and sleep-wake cycle) where these each represented a delirium core domain. The noncore symptom of lability of affect had high odds ratio for psychosis, while motor retardation reduced odds of psychosis in this model. Conclusions: Consistent with prior reports, psychosis occurred in less than half of delirious patients with delusions being infrequent, and an association with affective lability was found. Given that previous functional magnetic resonance imaging research found a correlation between neural network dysconnectivity with greater severity of delirium, psychotic symptoms might be a clinical marker for greater underlying cerebral cortical neural circuitry dysfunction.

Original languageEnglish
Pages (from-to)236-247
Number of pages12
JournalJournal of the Academy of Consultation-Liaison Psychiatry
Issue number3
StatePublished - 1 May 2023

Bibliographical note

Copyright © 2022 Academy of Consultation-Liaison Psychiatry. Published by Elsevier Inc. All rights reserved.


  • core domains
  • delirium
  • delusions
  • hallucinations
  • neural networks
  • psychosis

Types Minciencias

  • Artículos de investigación con calidad A2 / Q2


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