Dynamic mechanical analysis of agarose-based biopolymers with potential use in regenerative medicine

Sebastián Jaramillo-Isaza, Camilo Andrés Alfonso-Rodriguez, John Fredy Rios-Rojas, Jaime Alexis García-Guzmán

Research output: Contribution to journalConference and proceedingspeer-review

8 Scopus citations


Regenerative medicine is used for tissue healing, replace missing organs and tissues which are affected by aging, disease, or trauma both structurally and functionally. Materials are the key component of regenerative medicine approaches because the material can imitate the native extracellular matrix of those tissues and improve both the physical behavior and the properties of new tissue. However, most of the available materials used for that purpose fail to provide adequate mechanical properties to replicate the behavior of the original tissue. Thus, most of these applications are still far from being enduring. This project aims to determine the multi-scale mechanical properties of some biopolymers with potential use in regenerative medicine. In this very first part, Dynamic Mechanical Analysis (DMA) was performed using shear mode on different type VII agarose-based biopolymers at room temperature during 10 min cycles at 1 Hz frequency. On one hand, samples of fibrine-agarose were tested, and on the other, different compositions of chitosan-agarose, while pure type VII agarose was used as control. Computed values for the storage and loss modulus and the small values for Tan delta ratio (tan d) show that all materials become elastic, and they have a good capacity to dissipate energy per cycle of deformation. This fact means that all materials are suitable for being used as a scaffold for cell culture, a possible material for bioprinting applications and they could have potential use in regenerative medicine.

Original languageEnglish
Pages (from-to)16-22
Number of pages7
JournalMaterials Today: Proceedings
StatePublished - 2022
Event1st International Virtual Conference on Mechanical Engineering Trends, MET 2021 - Virtual, Online, Ecuador
Duration: 24 Mar 202126 Mar 2021

Bibliographical note

Publisher Copyright:
© 2022 Elsevier Ltd. All rights reserved.


  • Agarose
  • Biopolymer
  • Chitosan
  • Dynamic Mechanical Analysis
  • Fibrin
  • Regenerative Medicine

Types Minciencias

  • Artículos de investigación con calidad D


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