Effect of freezing temperature on the properties of lyophilized silk sericin scaffold

Maria C. Arango, Catalina Álvarez-López

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    3 Scopus citations

    Abstract

    Silk sericin (SS) can be used as biomaterials in the development of scaffolds for skin regeneration as it has important properties such as antioxidant capacity and biocompatibility. However, SS-based materials have weak structural properties, thereby making its application difficult. The effect of freezing temperature (-35 °C and -80 °C) on the properties of freeze-dried SS scaffolds is evaluated in this study. The secondary structure, morphology, and thermal stability of the scaffolds were determined x-ray diffraction and Fourier-transform infrared spectroscopy; scanning electron microscopy; and thermogravimetric analysis and differential scanning calorimetry, respectively. Its water absorption capacity was also assessed. The results indicated that scaffolds manufactured at -35 °C have a higher β-sheet content (37.08%), lower pore density, and larger porosity than those frozen at -80 °C. However, the water absorption and thermal properties showed no statistically significant differences between both samples.

    Original languageEnglish
    Article number095414
    JournalMaterials Research Express
    Volume6
    Issue number9
    DOIs
    StatePublished - 2 Aug 2019

    Bibliographical note

    Publisher Copyright:
    © 2019 IOP Publishing Ltd.

    Keywords

    • freezing
    • lyophilization
    • scaffold
    • Silk sericin

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