El papel de la enfermedad de von willebrand en la hemorragia uterina anormal

Translated title of the contribution: Von willebrand disease in abnormal uterine bleeding

Laura Isabel Jaramillo Jaramillo, Lina María Martínez Sánchez, Mabel Dahiana Tabares Roldán

    Research output: Contribution to journalReview articlepeer-review


    Abnormal uterine bleeding is a term used for alterations in the regularity, duration and / or volume of menstrual bleeding and it is considered a common cause of medical consultation; sometimes it is a diagnostic challenge for the treating physician. Within the aetiology approach of said pathology, coagulopathies affect around 13% of women, and the most common is von Willebrand disease. The objective is to review the current scientific literature on the influence of von Willebrand disease in abnormal uterine bleeding. This is an inherited pathology derived from a deficiency of the von Willebrand factor responsible for platelet adhesion. The prevalence of this disease may be low, however, when studying the population of women with menorrhagia, the frequency can range from 5 to 20%. Different gynecological problems associated with von Willebrand disease have been described, such as menorrhagia, dysmenorrhea and a significant iron deficiency associated with it, in addition to a higher incidence of ovarian cysts, endometriosis, endometrial hyperplasia and endometrial polyps. The current literature suggests that those women with suggestive clinical symptoms should be screened. Regarding treatment, the literature reports the use of tranexamic acid and oral contraceptives, nonetheless desmopressin has proven to be most useful.

    Translated title of the contributionVon willebrand disease in abnormal uterine bleeding
    Original languageSpanish
    Article numbere405
    Pages (from-to)1-11
    Number of pages11
    JournalRevista Cubana de Obstetricia y Ginecologia
    Issue number4
    StatePublished - 2019

    Bibliographical note

    Publisher Copyright:
    © 2019, Editorial Ciencias Medicas. All rights reserved.

    Types Minciencias

    • Artículos de investigación con calidad Q4


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