Ertapenem resistance in 2 tertiary-care hospitals: Microbiology, epidemiology, and risk factors

Natalia Maldonado; Bibiana Castro; Indira Berrio; Miguel Manjarrés; Carlos Robledo; Jaime Robledo

doi:10.1016/j.eimc.2015.11.009

Ertapenem resistance in 2 tertiary-care hospitals: Microbiology, epidemiology, and risk factors

Translated title of the contribution: Ertapenem resistance in 2 tertiary-care hospitals: Microbiology, epidemiology, and risk factors

Natalia Maldonado
, Bibiana Castro
, Indira Berrio
, Miguel Manjarrés
, Carlos Robledo
, Jaime Robledo

Research output: Contribution to scientific journal › Article in an indexed scientific journal › peer-review

4 Scopus citations

Abstract

Introduction Carbapenems resistance is a growing phenomenon and a threat to public health because of the reduced therapeutic options for resistant infections. Methods A retrospective case-control study was conducted in 2 tertiary-care hospitals in Medellín, Colombia. Fifty patients infected with ertapenem-resistant enterobacteriaceae were compared with a control group consisting of 100 patients with infections caused by ertapenem susceptible enterobacteriaceae. A multivariate logistic regression model was used to identify factors that best explain ertapenem-resistant enterobacteriaceae infections. Results The factors associated with ertapenem-resistant enterobacteriaceae infections were prior exposure to carbapenems (adjusted OR 3.43; 95% IC 1.08-10.87) and prior exposure to cefepime (adjusted OR 6.46; 95% IC 1.08-38.38). Conclusion Prior exposure to antibiotics is the factor that best explains the ertapenem-resistant enterobacteriaceae infection in this population, highlighting the importance of antimicrobial stewardship programs in hospitals.

Translated title of the contribution	Ertapenem resistance in 2 tertiary-care hospitals: Microbiology, epidemiology, and risk factors
Original language	English
Pages (from-to)	511-515
Number of pages	5
Journal	Enfermedades Infecciosas y Microbiologia Clinica
Volume	35
Issue number	8
DOIs	https://doi.org/10.1016/j.eimc.2015.11.009
State	Published - Oct 2017

Bibliographical note

Publisher Copyright:
© 2015 Elsevier España, S.L.U. y Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Carbapenem resistance
Carbapenems
Enterobacteriaceae infections
Risk factors

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10.1016/j.eimc.2015.11.009

Cite this

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title = "Ertapenem resistance in 2 tertiary-care hospitals: Microbiology, epidemiology, and risk factors",

abstract = "Introduction Carbapenems resistance is a growing phenomenon and a threat to public health because of the reduced therapeutic options for resistant infections. Methods A retrospective case-control study was conducted in 2 tertiary-care hospitals in Medell{\'i}n, Colombia. Fifty patients infected with ertapenem-resistant enterobacteriaceae were compared with a control group consisting of 100 patients with infections caused by ertapenem susceptible enterobacteriaceae. A multivariate logistic regression model was used to identify factors that best explain ertapenem-resistant enterobacteriaceae infections. Results The factors associated with ertapenem-resistant enterobacteriaceae infections were prior exposure to carbapenems (adjusted OR 3.43; 95\% IC 1.08-10.87) and prior exposure to cefepime (adjusted OR 6.46; 95\% IC 1.08-38.38). Conclusion Prior exposure to antibiotics is the factor that best explains the ertapenem-resistant enterobacteriaceae infection in this population, highlighting the importance of antimicrobial stewardship programs in hospitals.",

keywords = "Carbapenem resistance, Carbapenems, Enterobacteriaceae infections, Risk factors",

author = "Natalia Maldonado and Bibiana Castro and Indira Berrio and Miguel Manjarr{\'e}s and Carlos Robledo and Jaime Robledo",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Espa{\~n}a, S.L.U. y Sociedad Espa{\~n}ola de Enfermedades Infecciosas y Microbiolog{\'i}a Cl{\'i}nica",

year = "2017",

month = oct,

doi = "10.1016/j.eimc.2015.11.009",

language = "Ingl{\'e}s",

volume = "35",

pages = "511--515",

journal = "Enfermedades Infecciosas y Microbiologia Clinica",

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T1 - Ertapenem resistance in 2 tertiary-care hospitals

T2 - Microbiology, epidemiology, and risk factors

AU - Maldonado, Natalia

AU - Castro, Bibiana

AU - Berrio, Indira

AU - Manjarrés, Miguel

AU - Robledo, Carlos

AU - Robledo, Jaime

PY - 2017/10

Y1 - 2017/10

N2 - Introduction Carbapenems resistance is a growing phenomenon and a threat to public health because of the reduced therapeutic options for resistant infections. Methods A retrospective case-control study was conducted in 2 tertiary-care hospitals in Medellín, Colombia. Fifty patients infected with ertapenem-resistant enterobacteriaceae were compared with a control group consisting of 100 patients with infections caused by ertapenem susceptible enterobacteriaceae. A multivariate logistic regression model was used to identify factors that best explain ertapenem-resistant enterobacteriaceae infections. Results The factors associated with ertapenem-resistant enterobacteriaceae infections were prior exposure to carbapenems (adjusted OR 3.43; 95% IC 1.08-10.87) and prior exposure to cefepime (adjusted OR 6.46; 95% IC 1.08-38.38). Conclusion Prior exposure to antibiotics is the factor that best explains the ertapenem-resistant enterobacteriaceae infection in this population, highlighting the importance of antimicrobial stewardship programs in hospitals.

AB - Introduction Carbapenems resistance is a growing phenomenon and a threat to public health because of the reduced therapeutic options for resistant infections. Methods A retrospective case-control study was conducted in 2 tertiary-care hospitals in Medellín, Colombia. Fifty patients infected with ertapenem-resistant enterobacteriaceae were compared with a control group consisting of 100 patients with infections caused by ertapenem susceptible enterobacteriaceae. A multivariate logistic regression model was used to identify factors that best explain ertapenem-resistant enterobacteriaceae infections. Results The factors associated with ertapenem-resistant enterobacteriaceae infections were prior exposure to carbapenems (adjusted OR 3.43; 95% IC 1.08-10.87) and prior exposure to cefepime (adjusted OR 6.46; 95% IC 1.08-38.38). Conclusion Prior exposure to antibiotics is the factor that best explains the ertapenem-resistant enterobacteriaceae infection in this population, highlighting the importance of antimicrobial stewardship programs in hospitals.

KW - Carbapenem resistance

KW - Carbapenems

KW - Enterobacteriaceae infections

KW - Risk factors

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DO - 10.1016/j.eimc.2015.11.009

M3 - Artículo en revista científica indexada

C2 - 26778651

AN - SCOPUS:84954306471

SN - 0213-005X

VL - 35

SP - 511

EP - 515

JO - Enfermedades Infecciosas y Microbiologia Clinica

JF - Enfermedades Infecciosas y Microbiologia Clinica

IS - 8

ER -

Ertapenem resistance in 2 tertiary-care hospitals: Microbiology, epidemiology, and risk factors

Abstract

Bibliographical note

UN SDGs

Keywords

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