TY - JOUR
T1 - Evaluación de las características operativas de la relación proteína / creatinina en orina ocasional para la detección de proteinuria significativa en gestantes con sospecha de preeclampsia
AU - Restrepo-Moreno, Mónica
AU - Arango-Buitrago, Victoria
AU - Gil-Pabón, Christian José
AU - Campo-Campo, María Nazareth
AU - García-Posada, Raúl Alejandro
AU - Gutiérrez-Marín, Jorge Hernán
AU - Sanín-Blair, José Enrique
AU - Echavarría-Restrepo, Luis Guillermo
PY - 2016
Y1 - 2016
N2 - Objective: To analyse the sensitivity and specificity of the protein/creatinine ratio in the urine as a method for detecting proteinuria in women with suspected preeclampsia, considering 24-hour proteinuria as the gold standard. Materials and methods: Cross-sectional study that included women with more than 20 weeks of gestation, admitted to Clinica Universitaria Bolivariana in Medellin because of suspected preeclampsia. Pregnant women with urinary infection at the time of the study, patients with a history of chronic diseases that could cause proteinuria, and women who did not complete the sample collection were excluded. Urine protein/creatinine ratio as well as proteinuria were measured in all the patients included in the study. The correlation between the two tests and the cutoff point for the protein/creatinine ratio with the best performance for the detection of significant proteinuria were evaluated. Results: Overall, 200 urine samples were included and significant proteinuria was found in 27 % of the total number of samples. The protein/creatinine ratio in occasional urine was found to have a high correlation with 24-hour proteinuria(r = 0.775, p < 0.01). The cut-off point with the best performance for detecting significant proteinuria was found to be 0.30 mg /mg, with an 83 % sensitivity and a 98 % specificity, with a positive LR of 60 and a negative LR of 0.17. Conclusion: The protein/creatinine ratio in occasional urine may be used as a fast alternative method for determining the presence of proteinuria in patients with suspected preeclampsia.
AB - Objective: To analyse the sensitivity and specificity of the protein/creatinine ratio in the urine as a method for detecting proteinuria in women with suspected preeclampsia, considering 24-hour proteinuria as the gold standard. Materials and methods: Cross-sectional study that included women with more than 20 weeks of gestation, admitted to Clinica Universitaria Bolivariana in Medellin because of suspected preeclampsia. Pregnant women with urinary infection at the time of the study, patients with a history of chronic diseases that could cause proteinuria, and women who did not complete the sample collection were excluded. Urine protein/creatinine ratio as well as proteinuria were measured in all the patients included in the study. The correlation between the two tests and the cutoff point for the protein/creatinine ratio with the best performance for the detection of significant proteinuria were evaluated. Results: Overall, 200 urine samples were included and significant proteinuria was found in 27 % of the total number of samples. The protein/creatinine ratio in occasional urine was found to have a high correlation with 24-hour proteinuria(r = 0.775, p < 0.01). The cut-off point with the best performance for detecting significant proteinuria was found to be 0.30 mg /mg, with an 83 % sensitivity and a 98 % specificity, with a positive LR of 60 and a negative LR of 0.17. Conclusion: The protein/creatinine ratio in occasional urine may be used as a fast alternative method for determining the presence of proteinuria in patients with suspected preeclampsia.
KW - Preeclampsia
KW - Proteinuria
KW - Sensitivity and specificity
UR - http://www.scopus.com/inward/record.url?scp=84995559923&partnerID=8YFLogxK
U2 - 10.18597/rcog.770
DO - 10.18597/rcog.770
M3 - Artículo
AN - SCOPUS:84995559923
VL - 67
SP - 223
EP - 230
JO - Revista Colombiana de Obstetricia y Ginecologia
JF - Revista Colombiana de Obstetricia y Ginecologia
SN - 0034-7434
IS - 3
ER -