International analgesia, sedation, and delirium practices: A prospective cohort study

Gary D. Owen, Joanna L. Stollings, Shayan Rakhit, Li Wang, Chang Yu, Morgan A. Hosay, James W. Stewart, Fernando Frutos-Vivar, Oscar Peñuelas, Andres Esteban, Antonio R. Anzueto, Konstantinos Raymondos, Fernando Rios, Arnaud W. Thille, Marco González, Bin Du, Salvatore M. Maggiore, Dimitrios Matamis, Fekri Abroug, Pravin AminAmine Ali Zeggwagh, Mayur B. Patel

    Research output: Contribution to journalArticle in an indexed scientific journalpeer-review

    14 Scopus citations


    Background: While understanding of critical illness and delirium continue to evolve, the impact on clinical practice is often unknown and delayed. Our purpose was to provide insight into practice changes by characterizing analgesia and sedation usage and occurrence of delirium in different years and international regions. Methods: We performed a retrospective analysis of two multicenter, international, prospective cohort studies. Mechanically ventilated adults were followed for up to 28 days in 2010 and 2016. Proportion of days utilizing sedation, analgesia, and performance of a spontaneous awakening trial (SAT), and occurrence of delirium were described for each year and region and compared between years. Results: A total of 14,281 patients from 6 international regions were analyzed. Proportion of days utilizing analgesia and sedation increased from 2010 to 2016 (p < 0.001 for each). Benzodiazepine use decreased in every region but remained the most common sedative in Africa, Asia, and Latin America. Performance of SATs increased overall, driven mostly by the US/Canada region (24 to 35% of days with sedation, p < 0.001). Any delirium during admission increased from 7 to 8% of patients overall and doubled in the US/Canada region (17 to 36%, p < 0.001). Conclusions: Analgesia and sedation practices varied widely across international regions and significantly changed over time. Opportunities for improvement in care include increasing delirium monitoring, performing SATs, and decreasing use of sedation, particularly benzodiazepines.

    Original languageEnglish
    Article number25
    JournalJournal of Intensive Care
    StatePublished - 2019

    Bibliographical note

    Publisher Copyright:
    © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License


    • Agitation
    • Analgesia
    • Critical illness
    • Delirium
    • Mechanical ventilation

    Types Minciencias

    • Artículos de investigación con calidad A2 / Q2


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