Microvessel density and VEGF expression in pituitaries of pregnant women

Fabio Rotondo; Angelo Rotondo; Mark Jentoft; Bernd W. Scheithauer; Luis V. Syro; Jorge H. Donado; James E. Tarara; Kalman Kovacs

doi:10.14310/horm.2002.1413

Microvessel density and VEGF expression in pituitaries of pregnant women

Fabio Rotondo, Angelo Rotondo, Mark Jentoft, Bernd W. Scheithauer, Luis V. Syro, Jorge H. Donado, James E. Tarara, Kalman Kovacs

Research output: Contribution to journal › Article in an indexed scientific journal › peer-review

2 Scopus citations

Abstract

OBJECTIVE: In pregnant women, the pituitary is enlarged and the prolactin (PRL) secreting cells increase in size and number. This PRL cell hyperplasia is associated with hyperprolactinemia. The aim of the present work was to investigate adenohypophysial vascularization and immunoexpression of vascular endothelial growth factor (VEGF) in pituitaries of pregnant and post-partum women and compare the results with age-matched adenohypophyses of nonpregnant women who had no endocrine diseases. DESIGN: Pituitaries (n=18) obtained by autopsy from female patients of reproductive age who had died during pregnancy, after abortion or during post-partum were immunostained for CD-34 and VEGF using the streptavidinbiotin-peroxidase complex method. RESULTS: The results showed that microvessel densities and VEGF immunoexpression in the adenohypophyses of pregnant and post-partum women were similar to those found in the control pituitaries. CONCLUSION: It can be concluded that pituitary enlargement and PRL cell hyperplasia in pregnant women may occur without neovascularization and increased VEGF immunoexpression.

Original language	English
Pages (from-to)	292-297
Number of pages	6
Journal	Hormones
Volume	12
Issue number	2
DOIs	https://doi.org/10.14310/horm.2002.1413
State	Published - 2013

Keywords

Angiogenesis
Immunohistochemistry
Pituitary
Pregnancy
Vascular endothelial growth factor

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.14310/horm.2002.1413

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title = "Microvessel density and VEGF expression in pituitaries of pregnant women",

abstract = "OBJECTIVE: In pregnant women, the pituitary is enlarged and the prolactin (PRL) secreting cells increase in size and number. This PRL cell hyperplasia is associated with hyperprolactinemia. The aim of the present work was to investigate adenohypophysial vascularization and immunoexpression of vascular endothelial growth factor (VEGF) in pituitaries of pregnant and post-partum women and compare the results with age-matched adenohypophyses of nonpregnant women who had no endocrine diseases. DESIGN: Pituitaries (n=18) obtained by autopsy from female patients of reproductive age who had died during pregnancy, after abortion or during post-partum were immunostained for CD-34 and VEGF using the streptavidinbiotin-peroxidase complex method. RESULTS: The results showed that microvessel densities and VEGF immunoexpression in the adenohypophyses of pregnant and post-partum women were similar to those found in the control pituitaries. CONCLUSION: It can be concluded that pituitary enlargement and PRL cell hyperplasia in pregnant women may occur without neovascularization and increased VEGF immunoexpression.",

keywords = "Angiogenesis, Immunohistochemistry, Pituitary, Pregnancy, Vascular endothelial growth factor",

author = "Fabio Rotondo and Angelo Rotondo and Mark Jentoft and Scheithauer, {Bernd W.} and Syro, {Luis V.} and Donado, {Jorge H.} and Tarara, {James E.} and Kalman Kovacs",

year = "2013",

doi = "10.14310/horm.2002.1413",

language = "Ingl{\'e}s",

volume = "12",

pages = "292--297",

journal = "Hormones",

issn = "1109-3099",

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TY - JOUR

T1 - Microvessel density and VEGF expression in pituitaries of pregnant women

AU - Rotondo, Fabio

AU - Rotondo, Angelo

AU - Jentoft, Mark

AU - Scheithauer, Bernd W.

AU - Syro, Luis V.

AU - Donado, Jorge H.

AU - Tarara, James E.

AU - Kovacs, Kalman

PY - 2013

Y1 - 2013

N2 - OBJECTIVE: In pregnant women, the pituitary is enlarged and the prolactin (PRL) secreting cells increase in size and number. This PRL cell hyperplasia is associated with hyperprolactinemia. The aim of the present work was to investigate adenohypophysial vascularization and immunoexpression of vascular endothelial growth factor (VEGF) in pituitaries of pregnant and post-partum women and compare the results with age-matched adenohypophyses of nonpregnant women who had no endocrine diseases. DESIGN: Pituitaries (n=18) obtained by autopsy from female patients of reproductive age who had died during pregnancy, after abortion or during post-partum were immunostained for CD-34 and VEGF using the streptavidinbiotin-peroxidase complex method. RESULTS: The results showed that microvessel densities and VEGF immunoexpression in the adenohypophyses of pregnant and post-partum women were similar to those found in the control pituitaries. CONCLUSION: It can be concluded that pituitary enlargement and PRL cell hyperplasia in pregnant women may occur without neovascularization and increased VEGF immunoexpression.

AB - OBJECTIVE: In pregnant women, the pituitary is enlarged and the prolactin (PRL) secreting cells increase in size and number. This PRL cell hyperplasia is associated with hyperprolactinemia. The aim of the present work was to investigate adenohypophysial vascularization and immunoexpression of vascular endothelial growth factor (VEGF) in pituitaries of pregnant and post-partum women and compare the results with age-matched adenohypophyses of nonpregnant women who had no endocrine diseases. DESIGN: Pituitaries (n=18) obtained by autopsy from female patients of reproductive age who had died during pregnancy, after abortion or during post-partum were immunostained for CD-34 and VEGF using the streptavidinbiotin-peroxidase complex method. RESULTS: The results showed that microvessel densities and VEGF immunoexpression in the adenohypophyses of pregnant and post-partum women were similar to those found in the control pituitaries. CONCLUSION: It can be concluded that pituitary enlargement and PRL cell hyperplasia in pregnant women may occur without neovascularization and increased VEGF immunoexpression.

KW - Angiogenesis

KW - Immunohistochemistry

KW - Pituitary

KW - Pregnancy

KW - Vascular endothelial growth factor

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U2 - 10.14310/horm.2002.1413

DO - 10.14310/horm.2002.1413

M3 - Artículo en revista científica indexada

C2 - 23933698

AN - SCOPUS:84880732384

SN - 1109-3099

VL - 12

SP - 292

EP - 297

JO - Hormones

JF - Hormones

IS - 2

ER -

Microvessel density and VEGF expression in pituitaries of pregnant women

Abstract

Keywords

UN SDGs

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