Mutations in DNA repair genes are associated with the Haarlem lineage of Mycobacterium tuberculosis independently of their antibiotic resistance

Juanita Olano; Beatriz López; Alejandro Reyes; María del Pilar Lemos; Nidia Correa; Patricia Del Portillo; Lucia Barrera; Jaime Robledo; Viviana Ritacco; María Mercedes Zambrano

doi:10.1016/j.tube.2007.05.011

Mutations in DNA repair genes are associated with the Haarlem lineage of Mycobacterium tuberculosis independently of their antibiotic resistance

Juanita Olano
, Beatriz López
, Alejandro Reyes
, María del Pilar Lemos
, Nidia Correa
, Patricia Del Portillo
, Lucia Barrera
, Jaime Robledo
, Viviana Ritacco
, María Mercedes Zambrano

Research output: Contribution to scientific journal › Article in an indexed scientific journal › peer-review

22 Scopus citations

Abstract

The analysis of the DNA repair genes ogt and ung was carried out in 117 Mycobacterium tuberculosis clinical isolates from Argentina and Colombia in order to explore correlation between mutations in these genes and multi-drug resistance. With the exception of two Beijing family isolates, the rest of the strains harbored either two wild-type or two mutant alleles with identical single nucleotide polymorphisms (SNPs) in each gene (ogt44 and ung501). These ogt44 and ung501 mutations were not associated with multi-drug resistance and occurred simultaneously in circulating Haarlem genotype M. tuberculosis strains. We therefore propose the use of these markers as tools in phylogenetic and epidemiologic studies.

Original language	English
Pages (from-to)	502-508
Number of pages	7
Journal	Tuberculosis
Volume	87
Issue number	6
DOIs	https://doi.org/10.1016/j.tube.2007.05.011
State	Published - Nov 2007

Bibliographical note

Funding Information:
This work was partially funded by Colciencias (No. 65700418076 and RC No. 431-2004), SeCyT (PICT No. 05-09978) and the European Commission (EC-LSHP-CT-516028).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

DNA repair enzymes
Multi-drug resistant tuberculosis
Mycobacterium tuberculosis
Single nucleotide polymorphism

Access to Document

10.1016/j.tube.2007.05.011

Cite this

Olano, J., López, B., Reyes, A., del Pilar Lemos, M., Correa, N., Del Portillo, P., Barrera, L., Robledo, J., Ritacco, V., & Mercedes Zambrano, M. (2007). Mutations in DNA repair genes are associated with the Haarlem lineage of Mycobacterium tuberculosis independently of their antibiotic resistance. Tuberculosis, 87(6), 502-508. https://doi.org/10.1016/j.tube.2007.05.011

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title = "Mutations in DNA repair genes are associated with the Haarlem lineage of Mycobacterium tuberculosis independently of their antibiotic resistance",

abstract = "The analysis of the DNA repair genes ogt and ung was carried out in 117 Mycobacterium tuberculosis clinical isolates from Argentina and Colombia in order to explore correlation between mutations in these genes and multi-drug resistance. With the exception of two Beijing family isolates, the rest of the strains harbored either two wild-type or two mutant alleles with identical single nucleotide polymorphisms (SNPs) in each gene (ogt44 and ung501). These ogt44 and ung501 mutations were not associated with multi-drug resistance and occurred simultaneously in circulating Haarlem genotype M. tuberculosis strains. We therefore propose the use of these markers as tools in phylogenetic and epidemiologic studies.",

keywords = "DNA repair enzymes, Multi-drug resistant tuberculosis, Mycobacterium tuberculosis, Single nucleotide polymorphism",

author = "Juanita Olano and Beatriz L{\'o}pez and Alejandro Reyes and \{del Pilar Lemos\}, Mar{\'i}a and Nidia Correa and \{Del Portillo\}, Patricia and Lucia Barrera and Jaime Robledo and Viviana Ritacco and \{Mercedes Zambrano\}, Mar{\'i}a",

note = "Funding Information: This work was partially funded by Colciencias (No. 65700418076 and RC No. 431-2004), SeCyT (PICT No. 05-09978) and the European Commission (EC-LSHP-CT-516028). ",

year = "2007",

month = nov,

doi = "10.1016/j.tube.2007.05.011",

language = "Ingl{\'e}s",

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pages = "502--508",

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Olano, J, López, B, Reyes, A, del Pilar Lemos, M, Correa, N, Del Portillo, P, Barrera, L, Robledo, J, Ritacco, V & Mercedes Zambrano, M 2007, 'Mutations in DNA repair genes are associated with the Haarlem lineage of Mycobacterium tuberculosis independently of their antibiotic resistance', Tuberculosis, vol. 87, no. 6, pp. 502-508. https://doi.org/10.1016/j.tube.2007.05.011

Mutations in DNA repair genes are associated with the Haarlem lineage of Mycobacterium tuberculosis independently of their antibiotic resistance. / Olano, Juanita; López, Beatriz; Reyes, Alejandro et al.
In: Tuberculosis, Vol. 87, No. 6, 11.2007, p. 502-508.

Research output: Contribution to scientific journal › Article in an indexed scientific journal › peer-review

TY - JOUR

T1 - Mutations in DNA repair genes are associated with the Haarlem lineage of Mycobacterium tuberculosis independently of their antibiotic resistance

AU - Olano, Juanita

AU - López, Beatriz

AU - Reyes, Alejandro

AU - del Pilar Lemos, María

AU - Correa, Nidia

AU - Del Portillo, Patricia

AU - Barrera, Lucia

AU - Robledo, Jaime

AU - Ritacco, Viviana

AU - Mercedes Zambrano, María

N1 - Funding Information: This work was partially funded by Colciencias (No. 65700418076 and RC No. 431-2004), SeCyT (PICT No. 05-09978) and the European Commission (EC-LSHP-CT-516028).

PY - 2007/11

Y1 - 2007/11

N2 - The analysis of the DNA repair genes ogt and ung was carried out in 117 Mycobacterium tuberculosis clinical isolates from Argentina and Colombia in order to explore correlation between mutations in these genes and multi-drug resistance. With the exception of two Beijing family isolates, the rest of the strains harbored either two wild-type or two mutant alleles with identical single nucleotide polymorphisms (SNPs) in each gene (ogt44 and ung501). These ogt44 and ung501 mutations were not associated with multi-drug resistance and occurred simultaneously in circulating Haarlem genotype M. tuberculosis strains. We therefore propose the use of these markers as tools in phylogenetic and epidemiologic studies.

AB - The analysis of the DNA repair genes ogt and ung was carried out in 117 Mycobacterium tuberculosis clinical isolates from Argentina and Colombia in order to explore correlation between mutations in these genes and multi-drug resistance. With the exception of two Beijing family isolates, the rest of the strains harbored either two wild-type or two mutant alleles with identical single nucleotide polymorphisms (SNPs) in each gene (ogt44 and ung501). These ogt44 and ung501 mutations were not associated with multi-drug resistance and occurred simultaneously in circulating Haarlem genotype M. tuberculosis strains. We therefore propose the use of these markers as tools in phylogenetic and epidemiologic studies.

KW - DNA repair enzymes

KW - Multi-drug resistant tuberculosis

KW - Mycobacterium tuberculosis

KW - Single nucleotide polymorphism

UR - https://www.scopus.com/pages/publications/35348887751

U2 - 10.1016/j.tube.2007.05.011

DO - 10.1016/j.tube.2007.05.011

M3 - Artículo en revista científica indexada

C2 - 17919978

AN - SCOPUS:35348887751

SN - 1472-9792

VL - 87

SP - 502

EP - 508

JO - Tuberculosis

JF - Tuberculosis

IS - 6

ER -

Mutations in DNA repair genes are associated with the Haarlem lineage of Mycobacterium tuberculosis independently of their antibiotic resistance

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

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