Mycobacterium tuberculosis strains of the Beijing genotype are rarely observed in tuberculosis patients in South America

Viviana Ritacco, Beatriz López, Patricia I. Cafrune, Lucilaine Ferrazoli, Philip N. Suffys, Norma Candia, Lucy Vásquez, Teresa Realpe, Jorge Fernández, Karla V. Lima, Jeannete Zurita, Jaime Robledo, Maria L. Rossetti, Afranio L. Kritski, Maria A. Telles, Juan C. Palomino, Herre Heersma, Dick Van Soolingen, Kristin Kremer, Lucía Barrera

Research output: Contribution to journalArticle in an indexed scientific journalpeer-review

46 Scopus citations


The frequency of the Beijing genotype of Mycobacterium tuberculosis as a cause of tuberculosis (TB) in South America was determined by analyzing genotypes of strains isolated from patients that had been diagnosed with the disease between 1997 and 2003 in seven countries of the subcontinent. In total, 19 of the 1,202 (1.6%) TB cases carried Beijing isolates, including 11 of the 185 patients from Peru (5.9%), five of the 512 patients from Argentina (1.0%), two of the 252 Brazilian cases (0.8%), one of the 166 patients from Paraguay (0.6%) and none of the samples obtained from Chile (35), Colombia (36) and Ecuador (16). Except for two patients that were East Asian immigrants, all cases with Beijing strains were native South Americans. No association was found between carrying a strain with the Beijing genotype and having drug or multi-drug resistant disease. Our data show that presently transmission of M. tuberculosis strains of the Beijing genotype is not frequent in Latin America. In addition, the lack of association of drug resistant TB and infection with M. tuberculosis of the Beijing genotype observed presently demands efforts to define better the contribution of the virulence and lack of response to treatment to the growing spread of Beijing strains observed in other parts of the world.

Original languageEnglish
Pages (from-to)489-492
Number of pages4
JournalMemorias do Instituto Oswaldo Cruz
Issue number5
StatePublished - Aug 2008
Externally publishedYes


  • Beijing
  • Genotype
  • Latin America
  • Mycobacterium tuberculosis


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