Nonlinear measures characterize atrial fibrillatory dynamics generated using fractional diffusion

Juan Pablo Ugarte, S. I. Duque, A. Orozco Duque, C. Tobón, J. Bustamante, H. Andrade-Caicedo

Research output: Chapter in Book/Report/Conference proceedingConference and proceedingspeer-review

Abstract

Computational simulations are used as tool to study atrial fibrillation and its maintaining mechanisms. Phase analysis has been used to elucidate the mechanisms by which a reentry is generated. However, clinical application of phase mapping requires a signal preprocessing stage that could affect the activation sequences. In this work we use the fractional diffusion equation to generate fibrillatory dynamics, including stable and meandering rotors, and multiple wavelets, by varying the order of the spatial fractional derivatives obtaining different complexity levels of propagation in a 2D domain. We applied nonlinear measures to characterize the propagation patterns from electrograms. Our results show that electroanatomical maps constructed using approximate entropy and multifractal analysis, are able to detect the tip of stable and meandering rotors, and to mark the occurrence of collisions and wave breaks. Application of these signal processing techniques to clinical practice is feasible and could improve atrial fibrillation ablation procedures.

Original languageEnglish
Title of host publication7th Latin American Congress on Biomedical Engineering, CLAIB 2016
EditorsJohn Bustamante, Daniel A. Sierra, Isnardo Torres
PublisherSpringer Verlag
Pages541-544
Number of pages4
ISBN (Print)9789811040856
DOIs
StatePublished - 2017
Event7th Latin American Congress on Biomedical Engineering, CLAIB 2016 - Bucaramanga, Santander, Colombia
Duration: 26 Oct 201628 Oct 2016

Publication series

NameIFMBE Proceedings
Volume60
ISSN (Print)1680-0737

Conference

Conference7th Latin American Congress on Biomedical Engineering, CLAIB 2016
Country/TerritoryColombia
CityBucaramanga, Santander
Period26/10/1628/10/16

Bibliographical note

Publisher Copyright:
© Springer Nature Singapore Pte Ltd. 2017.

Keywords

  • Atrial fibrillation
  • Fractional diffusion
  • Nonlinear measures
  • Phase analysis
  • Rotors

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