Novel Strategies to Improve the Cardioprotective Effects of Cardioplegia

Estefanie Osorio-Llanes, Jairo Castellar-López, Wendy Rosales, Yuliet Montoya, John Busta-Mante, Ricardo Zalaquett, Roberto Bravo-Sagua, Jaime A. Riquelme, Gina Sánchez, Mario Chiong, Sergio Lavandero, Evelyn Mendoza-Torres

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

The use of cardioprotective strategies as adjuvants of cardioplegic solutions has be-come an ideal alternative for the improvement of post-surgery heart recovery. The choice of the optimal cardioplegia, as well as its distribution mechanism, remains controversial in the field of cardiovascular surgery. There is still a need to search for new and better cardioprotective methods during cardioplegic procedures. New techniques for the management of cardiovascular complications during cardioplegia have evolved with new alternatives and additives, and each new strategy provides a tool to neutralize the damage after ischemia/reperfusion events. Researchers and clinicians have committed themselves to studying the effect of new strategies and adjuvant components with the potential to improve the cardioprotective effect of cardioplegic solutions in preventing myocardial ischemia/reperfusion-induced injury during cardiac surgery. The aim of this review is to explore the different types of cardioplegia, their protection mechanisms, and which strategies have been proposed to enhance the function of these solutions in hearts exposed to cardiovascular pathologies that require surgical alternatives for their corrective progression.

Original languageEnglish
Article numbere240124226064
Pages (from-to)39-52
Number of pages14
JournalCurrent Cardiology Reviews
Volume20
Issue number1
DOIs
StatePublished - 2024

Bibliographical note

Publisher Copyright:
© 2024 Bentham Science Publishers.

Keywords

  • angiotensins
  • cardiac surgery
  • cardioplegia
  • cardioprotection
  • cardiovascular disease
  • ischemia/reperfusion

Types Minciencias

  • Artículos de investigación con calidad A2 / Q2

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