Practical optimal control for fed-batch bioreactors

Manuel J. Betancur, Jaime A. Moreno, Germán Buitron

    Research output: Contribution to journalConference articlepeer-review


    Optimal operation of fed-baich bioreactors is ail important practical issue. Since control actions are saturation-limited, the optimal control consists usually of both singular and bang-bang arcs. However, its realization requires good model knowledge and also measurement of all state variables, requirements hardly satisfied in real applications. In this paper a method is proposed, for a class of bioreactors, to robustly optimize the operation when few measurements are available and die model is uncertain. Such control law is justified and its properties analyzed. The class of processes addressed includes a biomass growth bioreactor and an experimental wastewater treatment plant for degrading toxicants.

    Original languageEnglish
    Pages (from-to)1437-1442
    Number of pages6
    Issue number13
    StatePublished - 2004
    Event6th IFAC Symposium on Nonlinear Control Systems, NOLCOS 2004 - Stuttgart, Germany
    Duration: 1 Sep 20043 Sep 2004

    Bibliographical note

    Funding Information:
    Thanks to CONACyT (project 34934A) and DGAPA for its financial support. This paper includes results of the EOLl project that is supported by the INCO program of the European Community, Contract number ICA4-Cf-2oo2-10012. M. J. Betancur thanks also the CE INCO-DEV bursary contract ICB l-Cf-2002-80006, UPB and CESAME. The scientific responsibility rests with the authors.

    Publisher Copyright:
    Copyright © 2004 IFAC.


    • Control applications
    • Fed-batch bioreactor
    • Optimal control
    • Robust control
    • Software sensor


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