Production of bioabsorbible nanoparticles of polycaprolactone by using a tubular recirculating system

G. Colmenares, L. Agudelo, R. Pinal, L. Hoyos

    Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

    2 Scopus citations

    Abstract

    Encapsulation and controlled release of substances using polymeric nanoparticles require that these have a high reproducibility, homogeneity, and control over their properties, especially when they are to be used in medical, pharmaceutical or nutritional applications among others. This work shows a system for synthesizing polymeric nanoparticles that can easily control the characteristics of nanoparticles. This study shows the effect of molecular weight of the polymer, the type of surfactant and the relationship between the volumes of the aqueous and the organic phases. It was found that the first two variables have a statistically significant effect on the diameter of the nanoparticles while the relationship between the volume of the aqueous phase and the organic phase does not significantly affect the diameter of the nanoparticles. Additionally, it was found that none of the three variables significantly affects the polydispersity index (PI) of the nanoparticles.

    Original languageEnglish
    Title of host publicationAdvanced Materials - TechConnect Briefs 2017
    EditorsMatthew Laudon, Fiona Case, Bart Romanowicz, Fiona Case
    PublisherTechConnect
    Pages395-398
    Number of pages4
    ISBN (Electronic)9780997511789
    StatePublished - 2017
    Event11th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 20th Annual Nanotech Conference and Expo, and the 2017 National SBIR/STTR Conference - Washington, United States
    Duration: 14 May 201717 May 2017

    Publication series

    NameAdvanced Materials - TechConnect Briefs 2017
    Volume1

    Conference

    Conference11th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 20th Annual Nanotech Conference and Expo, and the 2017 National SBIR/STTR Conference
    Country/TerritoryUnited States
    CityWashington
    Period14/05/1717/05/17

    Keywords

    • Delivery
    • Encapsulation
    • Nanoparticles
    • Nanoprecipitation
    • Polycaprolactone

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