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Production of bioabsorbible nanoparticles of polycaprolactone by using a tubular recirculating system

  • G. Colmenares
  • , L. Agudelo
  • , R. Pinal
  • , L. Hoyos

Research output: Chapter in Book/Conference proceedingConference and proceedingspeer-review

2 Scopus citations

Abstract

Encapsulation and controlled release of substances using polymeric nanoparticles require that these have a high reproducibility, homogeneity, and control over their properties, especially when they are to be used in medical, pharmaceutical or nutritional applications among others. This work shows a system for synthesizing polymeric nanoparticles that can easily control the characteristics of nanoparticles. This study shows the effect of molecular weight of the polymer, the type of surfactant and the relationship between the volumes of the aqueous and the organic phases. It was found that the first two variables have a statistically significant effect on the diameter of the nanoparticles while the relationship between the volume of the aqueous phase and the organic phase does not significantly affect the diameter of the nanoparticles. Additionally, it was found that none of the three variables significantly affects the polydispersity index (PI) of the nanoparticles.

Original languageEnglish
Title of host publicationAdvanced Materials - TechConnect Briefs 2017
EditorsMatthew Laudon, Fiona Case, Bart Romanowicz, Fiona Case
PublisherTechConnect
Pages395-398
Number of pages4
ISBN (Electronic)9780997511789
StatePublished - 2017
Event11th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 20th Annual Nanotech Conference and Expo, and the 2017 National SBIR/STTR Conference - Washington, United States
Duration: 14 May 201717 May 2017

Publication series

NameAdvanced Materials - TechConnect Briefs 2017
Volume1

Conference

Conference11th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 20th Annual Nanotech Conference and Expo, and the 2017 National SBIR/STTR Conference
Country/TerritoryUnited States
CityWashington
Period14/05/1717/05/17

Keywords

  • Delivery
  • Encapsulation
  • Nanoparticles
  • Nanoprecipitation
  • Polycaprolactone

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