Surface interactions between bacterial nanocellulose and B-complex vitamins

Diego Mauricio Sánchez-Osorno, Diego Gomez-Maldonado, Cristina Castro, María Soledad Peresin

    Research output: Contribution to journalArticleResearchpeer-review

    1 Scopus citations


    The interactions between films of bacterial nanocellulose (BNC) and B complex vitamins were studied using a Quartz Crystal Microbalance with Dissipation monitoring (QCM-D). Thin films of BNC were generated in situ by QCM-D, followed by real-time measurements of the vitamin adsorption. The desorption of vitamins was induced by rinsing the system using phosphate buffers at a pH of 2 and 6.5, emulating gastric conditions. Changes in frequency (which are proportional to changes in adsorbed mass, ∆m) detected by QCM-D were used to determine the amounts of vitamin adsorbed and released from the BNC film. Additionally, changes in dissipation (∆D) were proven to be useful in identifying the effects of the pH in both pristine cellulose films and films with vitamin pre-adsorbed, following its changes during release. The effects of pH on the morphology of the vitamin-BNC surfaces were also monitored by changes in rugosity from images obtained by atomic force microscopy (AFM). Based on this data, we propose a model for the binding phenomena, with the contraction on the relaxation of the cellulose film depending on pH, resulting in an efficient vitamin delivery process.

    Original languageEnglish
    Article number4041
    Issue number18
    StatePublished - Sep 2020

    Bibliographical note

    Funding Information:
    Funding: This work was supported by the USDA National Institute of Food and Agriculture, Hatch program (ALA013-17003) and McIntire-Stennis program (1022526). The School of Forestry and Wildlife Sciences at Auburn University also provided funding for this research. COLCIENCIAS (Departamento administrativo de Ciencia, Tecnología e Innovación)-Colombia supported the training of PhD students in Colombia.

    Publisher Copyright:
    © 2020 by the authors


    • Adsorption
    • Bacterial nanocellulose
    • QCM-D
    • Release
    • Vitamins


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