Synthesis and tautomeric studies of enamines from 1-(n-Hexyl)-3-methyl-2- pyrazolin-5-one

Julio Belmar, Fredy R. Pérez, Joel Alderete, Celia Zúñiga

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

1-(n-Hexyl)-3-methyl-2-pyrazolin-5-one was acylated with acid chlorides. Condensation of acyl derivatives with primary amines afforded enamines. According to the 1H and 13C NMR data, the acyl derivatives have mainly a 4-acylpyrazol-5-ol structure with intramolecular hydrogen bond, and the 4-aminomethylene derivatives exist predominantly in the enamine form stabilized by the same type of interaction.

Original languageEnglish
Pages (from-to)179-189
Number of pages11
JournalJournal of the Brazilian Chemical Society
Volume16
Issue number2
DOIs
StatePublished - 2005
Externally publishedYes

Keywords

  • Acylation
  • Acylpyrazolones
  • Alkylpyrazolones
  • Enamines
  • Pyrazolones

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