Tailoring adaptive bioresorbable Mg-based scaffolds with directed plasma nanosynthesis for enhanced osseointegration and tunable resorption

Viviana M. Posada, Ana Civantos, Juan Ramírez, Patricia Fernández-Morales, Jean Paul Allain

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    Abstract

    Directed plasma nanosynthesis (DPNS) is a plasma-based surface modification process used to provide high-fidelity bioactive and bioresorbable interfaces for Mg-based foams having an average 500-μm pore size and containing main components of Al, Zn and Ca at bal., 3.3%, 1.11%, and 0.21%, respectively. Correlations of incident particle energies of 400–700 eV and room temperature, normal and off-normal incidence angles of 0° and 60°, respectively, and high-ion fluence conditions are combined to elicit a bioreactive Mg-foam surface. H2 evolution and pH levels of irradiated and non-irradiated Mg-foams were examined and correlated to the DPNS parameters. In situ X-ray photoelectron spectroscopy and focused ion-beam results have shown that energies of ~ 400–700 eV can control surface topography and composition, which, in turn, controls the foam-corrosion mechanism. Samples are immersed in Dulbecco's modified eagle media, and a synergistic reaction is found in which the irradiated samples enhance the formation of calcium–phosphate (CaP) phases to CaP ratios close to the hydroxylapatite phase that enhances bone-tissue regeneration. These results lead to a surface modification strategy that adjusts the interaction of the material and the environment without using a coating that could affect the geometry and the bulk properties of the porous material.

    Original languageEnglish
    Article number149388
    JournalApplied Surface Science
    Volume550
    DOIs
    StatePublished - 1 Jun 2021

    Bibliographical note

    Funding Information:
    This research was carried out in part in the Frederick Seitz Materials Research Laboratory Central Research Facilities, University of Illinois. We thank Micro and Nanotechnology Laboratory, and Beckman institute from the University of Illinois at Urbana-Champaign for the facilities used to obtain the analytical measurements. VP would like to thank Ministerio de Ciencia, Tecnología e Innovación (MINCIENCIAS), Colombia, for her Ph.D. scholarship (call 757-2016). The authors would like to thank Enago ( www.enago.com ) for the English language review.

    Funding Information:
    This research was carried out in part in the Frederick Seitz Materials Research Laboratory Central Research Facilities, University of Illinois. We thank Micro and Nanotechnology Laboratory, and Beckman institute from the University of Illinois at Urbana-Champaign for the facilities used to obtain the analytical measurements. VP would like to thank Ministerio de Ciencia, Tecnología e Innovación (MINCIENCIAS), Colombia, for her Ph.D. scholarship (call 757-2016). The authors would like to thank Enago (www.enago.com) for the English language review.

    Publisher Copyright:
    © 2021 Elsevier B.V.

    Keywords

    • Cellular metals
    • Corrosion
    • Directed plasma nanosynthesis
    • Ion-assisted Gibbsian segregation
    • Magnesium foam
    • Nanopatterning

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