Use of factor Xa inhibitors in antiphospholipid antibodies syndrome: A serie of 7 cases

Translated title of the contribution: Use of factor Xa inhibitors in antiphospholipid antibodies syndrome: A serie of 7 cases

Ricardo César Restrepo Correa, Carlos Jaime Velásquez Franco, Carolina Muñoz-Grajales, Luis Fernando Pinto Peñaranda, Javier Darío Márquez Hernández, Libia María Rodríguez Padilla, Miguel Antonio Mesa Navas

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    Background: Antiphospholipid syndrome is an autoimmune disease with antibodies against membrane phospholipids with mainly thrombotic and/or obstetric manifestations. Its treatment is generally based on indefinite anticoagulation, usually with warfarin, and which, for various factors, is not always feasible, making it necessary to use alternative therapies. Objective: To describe the experience with rivaroxaban in patients with antiphospholipid syndrome. Materials and methods: A descriptive study was conducted on subjects that met the 2006 Sydney criteria for antiphospholipid antibodies syndrome and received anticoagulation with rivaroxaban at 20 mg daily dose in 2 reference hospitals in Medellin, Colombia, between January 2012 and April 2015. Results: The study included 7 patients, with a mean age of 36 ± 10.8 years (range 23-55). Four patients had venous thrombosis, 5 arterial, 5 were positive for anticardiolipin antibodies, 3 reactive to lupus anticoagulant, 2 anti-β2 glycoprotein positive subjects, and one patient had triple antiphospholipid antibody positivity. The median time of warfarin use was 15 months (RIQ 1-36). The reasons for starting rivaroxaban were: bleeding (n = 2), sub-therapeutic coagulation ranges (n = 2), toxicoderma, gastrointestinal intolerance, and re-thrombosis (n = 1, each). The time of use was 17.9 ± 13.4 months (range: 3-34). There were 2 recurrent cases of thrombosis during follow-up, and no adverse events. Conclusion: The use of factor Xa inhibitors in a series of patients with antiphospholipid syndrome and unable to use warfarin showed an adequate safety profile; however, 2 recurrent episodes of venous thrombosis occurred.

    Translated title of the contributionUse of factor Xa inhibitors in antiphospholipid antibodies syndrome: A serie of 7 cases
    Original languageEnglish
    Pages (from-to)16-21
    Number of pages6
    JournalRevista Colombiana de Reumatologia
    Issue number1
    StatePublished - 1 Jan 2018

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    Publisher Copyright:
    © 2017 Asociación Colombiana de Reumatología


    • Antiphospholipid syndrome
    • Rivaroxaban
    • Warfarin

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