A novel functionalization method for carbon nanotubes to repel ox-LDL in treatments after stent placement

C. I. Santana; L. M. Hoyos; J. F. Pérez; J. Bustamante; A. G. García

doi:10.1016/j.msec.2017.05.002

A novel functionalization method for carbon nanotubes to repel ox-LDL in treatments after stent placement

C. I. Santana, L. M. Hoyos, J. F. Pérez, J. Bustamante, A. G. García

Producción científica: Contribución a una revista › Artículo en revista científica indexada › revisión exhaustiva

8 Citas (Scopus)

Resumen

Carbon nanotubes (CNT) can be chemically modified by doping or functionalization to change the chemical and surface properties. These characteristic makes to CNT candidates for multiple applications including medical field in cardiovascular area. A novel method to CNT functionalization by formation of two compounds: α-bromoacid and the organic compound 2-(methacryloyloxy) ethyl phosphorylcholine (MPC), will be discussed in this article. According to results, CNT are suggested like candidates to repel oxidized low-density lipoproteins (ox-LDL) to prevent restenosis. The electronegative character on surface of functionalized CNT (F-CNT) is shown by wettability analysis observing a repellent behaviour in contact with ox-LDL after functionalization route. Here we analyse the toxicity of CNT and F-CNT on HepG2 cell line and find no damage to the cell membrane of HepG2 cells in concentration at doses below 1 mg/ml.

Idioma original	Inglés
Páginas (desde-hasta)	30-36
Número de páginas	7
Publicación	Materials Science and Engineering C
Volumen	79
DOI	https://doi.org/10.1016/j.msec.2017.05.002
Estado	Publicada - 1 oct. 2017
Publicado de forma externa	Sí

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© 2017 Elsevier B.V.

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title = "A novel functionalization method for carbon nanotubes to repel ox-LDL in treatments after stent placement",

abstract = "Carbon nanotubes (CNT) can be chemically modified by doping or functionalization to change the chemical and surface properties. These characteristic makes to CNT candidates for multiple applications including medical field in cardiovascular area. A novel method to CNT functionalization by formation of two compounds: α-bromoacid and the organic compound 2-(methacryloyloxy) ethyl phosphorylcholine (MPC), will be discussed in this article. According to results, CNT are suggested like candidates to repel oxidized low-density lipoproteins (ox-LDL) to prevent restenosis. The electronegative character on surface of functionalized CNT (F-CNT) is shown by wettability analysis observing a repellent behaviour in contact with ox-LDL after functionalization route. Here we analyse the toxicity of CNT and F-CNT on HepG2 cell line and find no damage to the cell membrane of HepG2 cells in concentration at doses below 1 mg/ml.",

keywords = "Atherosclerosis, CNT, Ox-LDL, Phosphorylcholine, Repulsion",

author = "Santana, {C. I.} and Hoyos, {L. M.} and P{\'e}rez, {J. F.} and J. Bustamante and Garc{\'i}a, {A. G.}",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier B.V.",

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doi = "10.1016/j.msec.2017.05.002",

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T1 - A novel functionalization method for carbon nanotubes to repel ox-LDL in treatments after stent placement

AU - Santana, C. I.

AU - Hoyos, L. M.

AU - Pérez, J. F.

AU - Bustamante, J.

AU - García, A. G.

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Carbon nanotubes (CNT) can be chemically modified by doping or functionalization to change the chemical and surface properties. These characteristic makes to CNT candidates for multiple applications including medical field in cardiovascular area. A novel method to CNT functionalization by formation of two compounds: α-bromoacid and the organic compound 2-(methacryloyloxy) ethyl phosphorylcholine (MPC), will be discussed in this article. According to results, CNT are suggested like candidates to repel oxidized low-density lipoproteins (ox-LDL) to prevent restenosis. The electronegative character on surface of functionalized CNT (F-CNT) is shown by wettability analysis observing a repellent behaviour in contact with ox-LDL after functionalization route. Here we analyse the toxicity of CNT and F-CNT on HepG2 cell line and find no damage to the cell membrane of HepG2 cells in concentration at doses below 1 mg/ml.

AB - Carbon nanotubes (CNT) can be chemically modified by doping or functionalization to change the chemical and surface properties. These characteristic makes to CNT candidates for multiple applications including medical field in cardiovascular area. A novel method to CNT functionalization by formation of two compounds: α-bromoacid and the organic compound 2-(methacryloyloxy) ethyl phosphorylcholine (MPC), will be discussed in this article. According to results, CNT are suggested like candidates to repel oxidized low-density lipoproteins (ox-LDL) to prevent restenosis. The electronegative character on surface of functionalized CNT (F-CNT) is shown by wettability analysis observing a repellent behaviour in contact with ox-LDL after functionalization route. Here we analyse the toxicity of CNT and F-CNT on HepG2 cell line and find no damage to the cell membrane of HepG2 cells in concentration at doses below 1 mg/ml.

KW - Atherosclerosis

KW - CNT

KW - Ox-LDL

KW - Phosphorylcholine

KW - Repulsion

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U2 - 10.1016/j.msec.2017.05.002

DO - 10.1016/j.msec.2017.05.002

M3 - Artículo en revista científica indexada

C2 - 28629022

AN - SCOPUS:85018727515

SN - 0928-4931

VL - 79

SP - 30

EP - 36

JO - Materials Science and Engineering C

JF - Materials Science and Engineering C

ER -

A novel functionalization method for carbon nanotubes to repel ox-LDL in treatments after stent placement

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