Agar de capa delgada: Una opción costoefectiva para el diagnóstico rápido de tuberculosis multirresistente

José M. Hernández-Sarmiento, Milton A. Martínez-Negrete, Diana M. Castrillón-Velilla, Sergio A. Mejía-Espinosa, Gloria I. Mejía-Mesa, Elsa M. Zapata-Fernández, Sara Rojas-Jiménez, Andrés E. Marín-Castro, Jaime A. Robledo-Restrepo

    Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

    3 Citas (Scopus)

    Resumen

    Objective Using cost-benefit analysis for comparing the thin-layer agar culture method to the standard multiple proportion method used in diagnosing multidrugresistant tuberculosis (MDR TB). Methods A cost-benefit evaluation of two diagnostic tests was made at the Corporación para Investigaciones Biológicas (CIB) in Medellín, Colombia. Results 100 patients were evaluated; 10.8 % rifampicin resistance and 14.3 % isoniazid resistance were found. A computer-based decision tree model was used for cost-effectiveness analysis (Treeage Pro); the thin-layer agar culture method was most cost-effective, having 100 % sensitivity, specificity and predictive values for detecting rifampicin and isoniazid resistance. The multiple proportion method value was calculated as being US$ 71 having an average 49 day report time compared to US$ 18 and 14 days for the thin-layer agar culture method. Discussion New technologies have been developed for diagnosing tuberculosis which are apparently faster and more effective; their operating characteristics must be evaluated as must their effectiveness in terms of cost-benefit. The present study established that using thin-layer agar culture was cheaper, equally effective and could provide results more quickly than the traditional method. This implies that a patient could receive MDR TB treatment more quickly.

    Título traducido de la contribuciónThin layer agar represents a cost-effective alternative for the rapid diagnosis of multi-drug resistant tuberculosis
    Idioma originalEspañol
    Páginas (desde-hasta)101-113
    Número de páginas13
    PublicaciónRevista de Salud Publica
    Volumen16
    N.º1
    DOI
    EstadoPublicada - 1 ene. 2014

    Nota bibliográfica

    Publisher Copyright:
    © 2014, Universidad Nacional de Colombia. All rights reserved.

    Palabras clave

    • Cost-benefit analysis
    • Diagnosis
    • Multidrug-resistance
    • Mycobacterium tuberculosis
    • Tuberculosis

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