Alteration in the gene expression of the HepG2 cell line by exposure to particulate matter (PM) of diesel

Luz Yaneth Orozco-Jiménez; Verónica Estrada-Vélez; Diana Paola Cuesta-Castro; Juan Pablo Isaza; Francisco Molina; Jaime Palacio-B; María Elena Álvarez-Orozco; Isabel Ortiz-Trujillo

doi:10.15446/dyna.v89n221.99394

Alteration in the gene expression of the HepG2 cell line by exposure to particulate matter (PM) of diesel

Título traducido de la contribución: Alteración en la expresión de genes en la línea celular HepG2 por exposición a material particulado (MP) de diésel

Luz Yaneth Orozco-Jiménez, Verónica Estrada-Vélez, Diana Paola Cuesta-Castro, Juan Pablo Isaza, Francisco Molina, Jaime Palacio-B, María Elena Álvarez-Orozco, Isabel Ortiz-Trujillo

Producción científica: Contribución a una revista › Artículo en revista científica indexada › revisión exhaustiva

1 Cita (Scopus)

Resumen

Particulate matter (PM) less than 2.5 um emitted by diesel engines is responsible for the morbidity and mortality associated with air pollution. Alternative fuels have been implemented, but their potential toxic effects are still unknown. The objective of this article is to evaluate the in vitro toxicity of the organic extract of particulate matter emitted by a diesel engine powered by two different fuels. Following cell exposure to fossil diesel + 10% ethanol and fossil diesel extracts, mutagenicity, genotoxicity, and differential gene expression were evaluated. The results showed that the organic extracts of diesel PM + 10% ethanol were more biotoxic (p<0.05). More studies are needed to better understand the health effect of PM emissions from biofuel.

Título traducido de la contribución	Alteración en la expresión de genes en la línea celular HepG2 por exposición a material particulado (MP) de diésel
Idioma original	Inglés
Páginas (desde-hasta)	110-120
Número de páginas	11
Publicación	DYNA (Colombia)
Volumen	89
N.º	221
DOI	https://doi.org/10.15446/dyna.v89n221.99394
Estado	Publicada - 1 abr. 2022

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© The author; licensee Universidad Nacional de Colombia.

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title = "Alteration in the gene expression of the HepG2 cell line by exposure to particulate matter (PM) of diesel",

abstract = "Particulate matter (PM) less than 2.5 um emitted by diesel engines is responsible for the morbidity and mortality associated with air pollution. Alternative fuels have been implemented, but their potential toxic effects are still unknown. The objective of this article is to evaluate the in vitro toxicity of the organic extract of particulate matter emitted by a diesel engine powered by two different fuels. Following cell exposure to fossil diesel + 10% ethanol and fossil diesel extracts, mutagenicity, genotoxicity, and differential gene expression were evaluated. The results showed that the organic extracts of diesel PM + 10% ethanol were more biotoxic (p<0.05). More studies are needed to better understand the health effect of PM emissions from biofuel.",

keywords = "diesel, genotoxicity, mutagenicity, organic extraction, particulate matter, transcriptomics",

author = "Orozco-Jim{\'e}nez, {Luz Yaneth} and Ver{\'o}nica Estrada-V{\'e}lez and Cuesta-Castro, {Diana Paola} and Isaza, {Juan Pablo} and Francisco Molina and Jaime Palacio-B and {\'A}lvarez-Orozco, {Mar{\'i}a Elena} and Isabel Ortiz-Trujillo",

note = "Publisher Copyright: {\textcopyright} The author; licensee Universidad Nacional de Colombia.",

year = "2022",

month = apr,

day = "1",

doi = "10.15446/dyna.v89n221.99394",

language = "Ingl{\'e}s",

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pages = "110--120",

journal = "DYNA (Colombia)",

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Alteration in the gene expression of the HepG2 cell line by exposure to particulate matter (PM) of diesel. / Orozco-Jiménez, Luz Yaneth; Estrada-Vélez, Verónica; Cuesta-Castro, Diana Paola et al.
En: DYNA (Colombia), Vol. 89, N.º 221, 01.04.2022, p. 110-120.

Producción científica: Contribución a una revista › Artículo en revista científica indexada › revisión exhaustiva

TY - JOUR

T1 - Alteration in the gene expression of the HepG2 cell line by exposure to particulate matter (PM) of diesel

AU - Orozco-Jiménez, Luz Yaneth

AU - Estrada-Vélez, Verónica

AU - Cuesta-Castro, Diana Paola

AU - Isaza, Juan Pablo

AU - Molina, Francisco

AU - Palacio-B, Jaime

AU - Álvarez-Orozco, María Elena

AU - Ortiz-Trujillo, Isabel

N1 - Publisher Copyright: © The author; licensee Universidad Nacional de Colombia.

PY - 2022/4/1

Y1 - 2022/4/1

N2 - Particulate matter (PM) less than 2.5 um emitted by diesel engines is responsible for the morbidity and mortality associated with air pollution. Alternative fuels have been implemented, but their potential toxic effects are still unknown. The objective of this article is to evaluate the in vitro toxicity of the organic extract of particulate matter emitted by a diesel engine powered by two different fuels. Following cell exposure to fossil diesel + 10% ethanol and fossil diesel extracts, mutagenicity, genotoxicity, and differential gene expression were evaluated. The results showed that the organic extracts of diesel PM + 10% ethanol were more biotoxic (p<0.05). More studies are needed to better understand the health effect of PM emissions from biofuel.

AB - Particulate matter (PM) less than 2.5 um emitted by diesel engines is responsible for the morbidity and mortality associated with air pollution. Alternative fuels have been implemented, but their potential toxic effects are still unknown. The objective of this article is to evaluate the in vitro toxicity of the organic extract of particulate matter emitted by a diesel engine powered by two different fuels. Following cell exposure to fossil diesel + 10% ethanol and fossil diesel extracts, mutagenicity, genotoxicity, and differential gene expression were evaluated. The results showed that the organic extracts of diesel PM + 10% ethanol were more biotoxic (p<0.05). More studies are needed to better understand the health effect of PM emissions from biofuel.

KW - diesel

KW - genotoxicity

KW - mutagenicity

KW - organic extraction

KW - particulate matter

KW - transcriptomics

UR - http://www.scopus.com/inward/record.url?scp=85159924029&partnerID=8YFLogxK

U2 - 10.15446/dyna.v89n221.99394

DO - 10.15446/dyna.v89n221.99394

M3 - Artículo en revista científica indexada

AN - SCOPUS:85159924029

SN - 0012-7353

VL - 89

SP - 110

EP - 120

JO - DYNA (Colombia)

JF - DYNA (Colombia)

IS - 221

ER -

Alteration in the gene expression of the HepG2 cell line by exposure to particulate matter (PM) of diesel

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