Analysis of antibody binding specificities in twin and SNP-genotyped cohorts reveals that antiviral antibody epitope selection is a heritable trait

Thiagarajan Venkataraman, Cristian Valencia, Massimo Mangino, William Morgenlander, Steven J. Clipman, Thomas Liechti, Ana Valencia, Paraskevi Christofidou, Tim Spector, Mario Roederer, Priya Duggal, H. Benjamin Larman

    Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

    4 Citas (Scopus)

    Resumen

    Human immune responses to viral infections are highly variable, but the genetic factors that contribute to this variability are not well characterized. We used VirScan, a high-throughput epitope scanning technology, to analyze pan-viral antibody reactivity profiles of twins and SNP-genotyped individuals. Using these data, we determined the heritability and genomic loci associated with antibody epitope selection, response breadth, and control of Epstein-Barr virus (EBV) viral load. 107 EBV peptide reactivities were heritable and at least two Epstein-Barr nuclear antigen 2 (EBNA-2) reactivities were associated with variants in the MHC class II locus. We identified an EBV serosignature that predicted viral load in peripheral blood mononuclear cells and was associated with variants in the MHC class I locus. Our study illustrates the utility of epitope profiling to investigate the genetics of pathogen immunity, reports heritable features of the antibody response to viruses, and identifies specific HLA loci important for EBV epitope selection.

    Idioma originalInglés
    Páginas (desde-hasta)174-184.e5
    PublicaciónImmunity
    Volumen55
    N.º1
    DOI
    EstadoPublicada - 11 ene. 2022

    Nota bibliográfica

    Publisher Copyright:
    © 2021 Elsevier Inc.

    Huella

    Profundice en los temas de investigación de 'Analysis of antibody binding specificities in twin and SNP-genotyped cohorts reveals that antiviral antibody epitope selection is a heritable trait'. En conjunto forman una huella única.

    Citar esto