Anemia sideroblástica una enfermedad infrecuente de causas múltiples

Lina María Martínez-Sánchez, Santiago Castañeda Palacio

Resultado de la investigación: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

Resumen

Introduction: Sideroblastic anemia is a hematological disorder that alters the hematopoiesis process. This condition affects, to a great extent, the erythroid line. In addition, alterations occur in the synthesis of the heme group due to mitochondrial dysfunction in the bone marrow cells. Objective: To investigate sideroblastic anemia, its variables and the different types of presentation of this disease. Methods: A literature review was carried out in the MEDLINE, EMBASE, Lilacs and ScienceDirect databases, using the descriptors anemia sideroblástica [sideroblastic anemia], hematopoyesis [hematopoiesis], anomalías congénitas [congenital anomalies] and 5-aminolevulinato sintetasa [5-aminolevulinate synthetase], in Spanish and English. Twety-six articles related to the topic were selected. An analysis and summary of the revised bibliography was carried out. Information analysis and synthesis: It is a disease of congenital origin or secondary to other processes such as alcohol consumption or induced by some medications. It occurs infrequently and its diagnosis is mostly made through laboratory studies, such as peripheral blood smear and bone marrow study, to which various stains can be applied, as well as sequencing or even polymerase chain reaction. Conclusion: Sideroblastic anemia is a disease that can be related to other hematological alterations that modify iron metabolism. The curative treatment is the transfusion of blood components. An individualized approach should be used according to the type of sideroblastic anemia.

Título traducido de la contribuciónSideroblastic anemia, a rare disease of multiple causes
Idioma originalEspañol
Número de artículoe1201
Páginas (desde-hasta)1-14
Número de páginas14
PublicaciónRevista Cubana de Hematologia, Inmunologia y Hemoterapia
Volumen36
N.º3
EstadoPublicada - 2020
Publicado de forma externa

Nota bibliográfica

Publisher Copyright:
© 2020, Editorial Ciencias Medicas. All rights reserved.

Palabras clave

  • 5-aminolevulinate synthetase
  • Congenital anomalies
  • Hematopoiesis
  • Sideroblastic anemia

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