Association between ventilatory settings and development of acute respiratory distress syndrome in mechanically ventilated patients due to brain injury

VENTILA group

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

21 Citas (Scopus)

Resumen

Purpose In neurologically critically ill patients with mechanical ventilation (MV), the development of acute respiratory distress syndrome (ARDS) is a major contributor to morbidity and mortality, but the role of ventilatory management has been scarcely evaluated. We evaluate the association of tidal volume, level of PEEP and driving pressure with the development of ARDS in a population of patients with brain injury. Materials and methods We performed a secondary analysis of a prospective, observational study on mechanical ventilation. Results We included 986 patients mechanically ventilated due to an acute brain injury (hemorrhagic stroke, ischemic stroke or brain trauma). Incidence of ARDS in this cohort was 3%. Multivariate analysis suggested that driving pressure could be associated with the development of ARDS (odds ratio for unit increment of driving pressure 1.12; confidence interval for 95%: 1.01 to 1.23) whereas we did not observe association for tidal volume (in ml per kg of predicted body weight) or level of PEEP. ARDS was associated with an increase in mortality, longer duration of mechanical ventilation, and longer ICU length of stay. Conclusions In a cohort of brain-injured patients the development of ARDS was not common. Driving pressure was associated with the development of this disease.

Idioma originalInglés
Páginas (desde-hasta)341-345
Número de páginas5
PublicaciónJournal of Critical Care
Volumen38
DOI
EstadoPublicada - 1 abr. 2017
Publicado de forma externa

Nota bibliográfica

Publisher Copyright:
© 2016 Elsevier Inc.

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