Azopolymer based nanoparticles for phototriggered drug delivery

Sandra Perez-Buitrago, Pedro Mena-Giraldo, Rodolfo Pinal, Lina Hoyos-Palacio

Resultado de la investigación: Capítulo del libro/informe/acta de congresoContribución a la conferenciarevisión exhaustiva

4 Citas (Scopus)

Resumen

Controlled release by stimulus-responsive nanoparticles is oriented to increase the specificity of drug delivery, to improve the therapy effectiveness and minimizing side effects. This work presents the synthesis of photosensitive-polymeric nanoparticles as a potential system for localized drug delivery. First, the photoisomerizable amphiphilic-copolymer poly2-[4-phenylazophenoxy]ethyl acrylate-co-acrylic acid (PPAPE), was synthesized. Then, PPAPE was employed to prepare micellar nanoparticles by the nanoprecipitation method. Characterizations of the polymer were performed by proton nuclear magnetic resonance, X-ray photoelectron spectroscopy and FTIR spectroscopy. The morphology of the nanoparticles was analyzed by dynamic light scattering and transmission electron microscopy. Also, photostimulation response was confirmed by UV-VIS spectroscopy. Results indicate that the obtained photoresponsive nanoparticles have the size and photoisomerization necessary to perform the specific release of drugs.

Idioma originalInglés
Título de la publicación alojada2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019
EditorialInstitute of Electrical and Electronics Engineers Inc.
Páginas1089-1092
Número de páginas4
ISBN (versión digital)9781538613115
DOI
EstadoPublicada - jul. 2019
Publicado de forma externa
Evento41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019 - Berlin, Alemania
Duración: 23 jul. 201927 jul. 2019

Serie de la publicación

NombreProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (versión impresa)1557-170X

Conferencia

Conferencia41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019
País/TerritorioAlemania
CiudadBerlin
Período23/07/1927/07/19

Nota bibliográfica

Publisher Copyright:
© 2019 IEEE.

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