Controlled release by stimulus-responsive nanoparticles is oriented to increase the specificity of drug delivery, to improve the therapy effectiveness and minimizing side effects. This work presents the synthesis of photosensitive-polymeric nanoparticles as a potential system for localized drug delivery. First, the photoisomerizable amphiphilic-copolymer poly2-[4-phenylazophenoxy]ethyl acrylate-co-acrylic acid (PPAPE), was synthesized. Then, PPAPE was employed to prepare micellar nanoparticles by the nanoprecipitation method. Characterizations of the polymer were performed by proton nuclear magnetic resonance, X-ray photoelectron spectroscopy and FTIR spectroscopy. The morphology of the nanoparticles was analyzed by dynamic light scattering and transmission electron microscopy. Also, photostimulation response was confirmed by UV-VIS spectroscopy. Results indicate that the obtained photoresponsive nanoparticles have the size and photoisomerization necessary to perform the specific release of drugs.
|Título de la publicación alojada||2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019|
|Editorial||Institute of Electrical and Electronics Engineers Inc.|
|Número de páginas||4|
|ISBN (versión digital)||9781538613115|
|Estado||Publicada - jul. 2019|
|Publicado de forma externa||Sí|
|Evento||41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019 - Berlin, Alemania|
Duración: 23 jul. 2019 → 27 jul. 2019
Serie de la publicación
|Nombre||Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS|
|ISSN (versión impresa)||1557-170X|
|Conferencia||41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019|
|Período||23/07/19 → 27/07/19|
Nota bibliográficaPublisher Copyright:
© 2019 IEEE.