Azopolymer based nanoparticles for phototriggered drug delivery

Sandra Perez-Buitrago; Pedro Mena-Giraldo; Rodolfo Pinal; Lina Hoyos-Palacio

doi:10.1109/EMBC.2019.8856432

Azopolymer based nanoparticles for phototriggered drug delivery

Sandra Perez-Buitrago, Pedro Mena-Giraldo, Rodolfo Pinal, Lina Hoyos-Palacio

Producción científica: Capítulo del libro/informe/acta de congreso › Ponencia publicada en las memorias del evento con ISBN › revisión exhaustiva

6 Citas (Scopus)

Resumen

Controlled release by stimulus-responsive nanoparticles is oriented to increase the specificity of drug delivery, to improve the therapy effectiveness and minimizing side effects. This work presents the synthesis of photosensitive-polymeric nanoparticles as a potential system for localized drug delivery. First, the photoisomerizable amphiphilic-copolymer poly2-[4-phenylazophenoxy]ethyl acrylate-co-acrylic acid (PPAPE), was synthesized. Then, PPAPE was employed to prepare micellar nanoparticles by the nanoprecipitation method. Characterizations of the polymer were performed by proton nuclear magnetic resonance, X-ray photoelectron spectroscopy and FTIR spectroscopy. The morphology of the nanoparticles was analyzed by dynamic light scattering and transmission electron microscopy. Also, photostimulation response was confirmed by UV-VIS spectroscopy. Results indicate that the obtained photoresponsive nanoparticles have the size and photoisomerization necessary to perform the specific release of drugs.

Idioma original	Inglés
Título de la publicación alojada	2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019
Editorial	Institute of Electrical and Electronics Engineers Inc.
Páginas	1089-1092
Número de páginas	4
ISBN (versión digital)	9781538613115
DOI	https://doi.org/10.1109/EMBC.2019.8856432
Estado	Publicada - jul. 2019
Evento	41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019 - Berlin, Alemania Duración: 23 jul. 2019 → 27 jul. 2019

Serie de la publicación

Nombre	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (versión impresa)	1557-170X

Conferencia

Conferencia	41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019
País/Territorio	Alemania
Ciudad	Berlin
Período	23/07/19 → 27/07/19

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Publisher Copyright:
© 2019 IEEE.

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Perez-Buitrago, S., Mena-Giraldo, P., Pinal, R., & Hoyos-Palacio, L. (2019). Azopolymer based nanoparticles for phototriggered drug delivery. En 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019 (pp. 1089-1092). Artículo 8856432 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2019.8856432

Perez-Buitrago, Sandra ; Mena-Giraldo, Pedro ; Pinal, Rodolfo et al. / Azopolymer based nanoparticles for phototriggered drug delivery. 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019. Institute of Electrical and Electronics Engineers Inc., 2019. pp. 1089-1092 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

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title = "Azopolymer based nanoparticles for phototriggered drug delivery",

abstract = "Controlled release by stimulus-responsive nanoparticles is oriented to increase the specificity of drug delivery, to improve the therapy effectiveness and minimizing side effects. This work presents the synthesis of photosensitive-polymeric nanoparticles as a potential system for localized drug delivery. First, the photoisomerizable amphiphilic-copolymer poly2-[4-phenylazophenoxy]ethyl acrylate-co-acrylic acid (PPAPE), was synthesized. Then, PPAPE was employed to prepare micellar nanoparticles by the nanoprecipitation method. Characterizations of the polymer were performed by proton nuclear magnetic resonance, X-ray photoelectron spectroscopy and FTIR spectroscopy. The morphology of the nanoparticles was analyzed by dynamic light scattering and transmission electron microscopy. Also, photostimulation response was confirmed by UV-VIS spectroscopy. Results indicate that the obtained photoresponsive nanoparticles have the size and photoisomerization necessary to perform the specific release of drugs.",

author = "Sandra Perez-Buitrago and Pedro Mena-Giraldo and Rodolfo Pinal and Lina Hoyos-Palacio",

note = "Publisher Copyright: {\textcopyright} 2019 IEEE.; 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019 ; Conference date: 23-07-2019 Through 27-07-2019",

year = "2019",

month = jul,

doi = "10.1109/EMBC.2019.8856432",

language = "Ingl{\'e}s",

series = "Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS",

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Perez-Buitrago, S, Mena-Giraldo, P, Pinal, R & Hoyos-Palacio, L 2019, Azopolymer based nanoparticles for phototriggered drug delivery. En 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019., 8856432, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, Institute of Electrical and Electronics Engineers Inc., pp. 1089-1092, 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019, Berlin, Alemania, 23/07/19. https://doi.org/10.1109/EMBC.2019.8856432

Azopolymer based nanoparticles for phototriggered drug delivery. / Perez-Buitrago, Sandra; Mena-Giraldo, Pedro; Pinal, Rodolfo et al.
2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019. Institute of Electrical and Electronics Engineers Inc., 2019. p. 1089-1092 8856432 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

Producción científica: Capítulo del libro/informe/acta de congreso › Ponencia publicada en las memorias del evento con ISBN › revisión exhaustiva

TY - GEN

T1 - Azopolymer based nanoparticles for phototriggered drug delivery

AU - Perez-Buitrago, Sandra

AU - Mena-Giraldo, Pedro

AU - Pinal, Rodolfo

AU - Hoyos-Palacio, Lina

PY - 2019/7

Y1 - 2019/7

N2 - Controlled release by stimulus-responsive nanoparticles is oriented to increase the specificity of drug delivery, to improve the therapy effectiveness and minimizing side effects. This work presents the synthesis of photosensitive-polymeric nanoparticles as a potential system for localized drug delivery. First, the photoisomerizable amphiphilic-copolymer poly2-[4-phenylazophenoxy]ethyl acrylate-co-acrylic acid (PPAPE), was synthesized. Then, PPAPE was employed to prepare micellar nanoparticles by the nanoprecipitation method. Characterizations of the polymer were performed by proton nuclear magnetic resonance, X-ray photoelectron spectroscopy and FTIR spectroscopy. The morphology of the nanoparticles was analyzed by dynamic light scattering and transmission electron microscopy. Also, photostimulation response was confirmed by UV-VIS spectroscopy. Results indicate that the obtained photoresponsive nanoparticles have the size and photoisomerization necessary to perform the specific release of drugs.

AB - Controlled release by stimulus-responsive nanoparticles is oriented to increase the specificity of drug delivery, to improve the therapy effectiveness and minimizing side effects. This work presents the synthesis of photosensitive-polymeric nanoparticles as a potential system for localized drug delivery. First, the photoisomerizable amphiphilic-copolymer poly2-[4-phenylazophenoxy]ethyl acrylate-co-acrylic acid (PPAPE), was synthesized. Then, PPAPE was employed to prepare micellar nanoparticles by the nanoprecipitation method. Characterizations of the polymer were performed by proton nuclear magnetic resonance, X-ray photoelectron spectroscopy and FTIR spectroscopy. The morphology of the nanoparticles was analyzed by dynamic light scattering and transmission electron microscopy. Also, photostimulation response was confirmed by UV-VIS spectroscopy. Results indicate that the obtained photoresponsive nanoparticles have the size and photoisomerization necessary to perform the specific release of drugs.

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BT - 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019

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ER -

Perez-Buitrago S, Mena-Giraldo P, Pinal R, Hoyos-Palacio L. Azopolymer based nanoparticles for phototriggered drug delivery. En 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019. Institute of Electrical and Electronics Engineers Inc. 2019. p. 1089-1092. 8856432. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). doi: 10.1109/EMBC.2019.8856432

Azopolymer based nanoparticles for phototriggered drug delivery

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