Características de la videocapilaroscopia del lecho ungular y de los anticuerpos antinucleares en una cohorte de pacientes con enfermedad autoinmune sistémica con fenómeno de Raynaud

Andrea Facio-Lince García, Carlos Jaime Velásquez-Franco, Aura Ligia Zapata-Castellanos, Libia María Rodríguez-Padilla, Miguel Antonio Mesa-Navas

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

1 Cita (Scopus)

Resumen

Introduction: Between 15 and 20% of patients with Raynaud's phenomenon will progress to a systemic autoimmune disease. The presence of autoantibodies or capillaroscopy alterations are fundamental for early diagnosis. Objectives: To determine the characteristics of nailfold videocapillaroscopy and antinuclear antibodies in a cohort of patients with systemic autoimmune disease. Materials and methods: A cross-sectional study was conducted in subjects with Raynaud's phenomenon. These were evaluated with videocapillaroscopy and antinuclear antibodies. The qualitative variables were described with absolute and relative frequencies. The quantitative variables, according to the distribution of data, were reported as mean or median, with standard deviation and interquartile range, respectively. Results: The study included 58 individuals, of which 91.4% were women. The mean age was 40.9 ± 14.1 years. Antinuclear antibodies were positive in 41 subjects. The most common pattern was speckled (41.5%), with a median dilution of 1:640 (interquartile range 1:320-1:1,280). A systemic autoimmune disease was found in 10 (19.2%) patients, 8 of them with systemic sclerosis. The most frequent capillary alterations were: mega-capillaries (n = 10), micro-haemorrhages (n = 10), and avascular zones (n = 8). Conclusions: In this group of patients with Raynaud's phenomenon subjected to videocapillaroscopy, a diagnosis of systemic autoimmune disease was made in a similar percentage to that reported in the literature. A higher dilution of antinuclear antibodies was found than that described.

Título traducido de la contribuciónCharacteristics of nailfold videocapillaroscopy and antinuclear antibodies in a cohort of patients with systemic autoimmune disease with Raynaud's phenomenon
Idioma originalEspañol
Páginas (desde-hasta)169-176
Número de páginas8
PublicaciónRevista Colombiana de Reumatologia
Volumen25
N.º3
DOI
EstadoPublicada - 1 jul. 2018
Publicado de forma externa

Nota bibliográfica

Publisher Copyright:
© 2018 Asociación Colombiana de Reumatología

Palabras clave

  • Antinuclear antibodies
  • Autoimmune diseases
  • Microscopic angioscopy
  • Raynaud's disease

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Profundice en los temas de investigación de 'Características de la videocapilaroscopia del lecho ungular y de los anticuerpos antinucleares en una cohorte de pacientes con enfermedad autoinmune sistémica con fenómeno de Raynaud'. En conjunto forman una huella única.

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