Caracterización de mujeres embarazadas con lupus eritematoso sistémico y resultados materno-fetales en el noroeste de Colombia. Estudio descriptivo

Sara Manuela Ocampo-Ramirez, Simón Hoyos-Patiño, José Raúl Lambertino-Montaño, Jorge Hernán Gutiérrez-Marín, María Nazareth Campo-Campo, José Enrique Sanín-Blair, Raúl Alejandro García-Posada, Libia María Rodríguez-Padilla, Carlos Jaime Velásquez-Franco, Miguel Antonio Mesa-Navas

    Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

    Resumen

    Objective: To evaluate the epidemiological, clinical and therapeutic characteristics of pregnant women with systemic lupus erythematosus, as well as their obstetric results, in two reference centers in northwestern Colombia. Methods: Retrospective case series that evaluated the pregnant women seen in the Maternal-Fetal Medicine and Rheumatology Units between 2010 and 2015. Results: 40 patients and 43 pregnancies were included. The average age at diagnosis: 24 ± 7 years; 22 (55 %) were primigravidae. The most common clinical affectation was articular (n = 32, 80 %). Eight of 43 pregnancies (18.6 %) presented lupus activity at the beginning of gestation. The most frequent obstetric complication was preeclampsia in 11/43 (25.6 %) pregnancies. The most common fetal complication was preterm labor (8/43, 18.6 %). Anticardiolipin and anti-DNA antibodies were positive in 10/43 (23.3%) and in 15/38 (39.5 %) pregnancies, respectively. In 13 ges-tations (31.7 %), there were relapses during the third trimester, and of these, in six cases (46.1 %) there were severe especially nephritis. On admission, prednisone was used in 29/43 (65 %) pregnancies and antimala-rial drugs in 32/43 (74.4 %). In the puerperium, two patients had a moderate relapse and two mothers had preeclampsia. No maternal deaths were found and perinatal survival was 86% (37/43 pregnancies). Discussion: In this cohort of patients with systemic lupus erythematosus and pregnancy, nephritis and antiphospholipid antibodies were present in a large part of the patients with obstetric complications, although a low percentage of patients were active before gestation; maternal and fetal complications were frequent.

    Título traducido de la contribuciónCharacterization of pregnant women with systemic lupus erythematosus and maternofetal outcomes in northwestern Colombia: A descriptive study
    Idioma originalEspañol
    Páginas (desde-hasta)266-275
    Número de páginas10
    PublicaciónIatreia
    Volumen32
    N.º4
    EstadoPublicada - 2019

    Nota bibliográfica

    Publisher Copyright:
    © 2019, Universidad de Antioquia. All rights reserved.

    Palabras clave

    • Lupus Erythematosus
    • Pregnancy
    • Pregnancy Outcome
    • Systemic

    Huella

    Profundice en los temas de investigación de 'Caracterización de mujeres embarazadas con lupus eritematoso sistémico y resultados materno-fetales en el noroeste de Colombia. Estudio descriptivo'. En conjunto forman una huella única.

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