Caracterización y prevalencia de manifestaciones extraintestinales en una cohorte de pacientes con enfermedad inflamatoria intestinal en Medellín (Colombia)

Fabián Juliao-Baños, Mateo Arrubla, Laura Osorio, Joselyn Camargo, Juliana Londoño, Camilo Cáceres, Jhon Carvajal, Gabriel Mosquera-Klinger, Jorge Donado

    Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

    1 Cita (Scopus)

    Resumen

    Introduction: Extraintestinal manifestations (EIMs) are frequent in patients with inflammatory bowel disease (IBD). Our objective is to characterize and determine the prevalence of MEIs in our cohort of patients with IBD. Patients and methods: A retrospective study was carried out in adult patients with IBD at the Pablo Tobón Uribe Hospital in Medellín. Colombia. Articular MEIs, primary sclerosing cholangitis (PSC), both ophthalmological and dermatological, were considered. Absolute and relative frequencies were used. The Chi square test of independence was used to compare 2 proportions and the odds ratio (OR) was estimated. Results: Our registry has 759 patients with IBD, 544 present UC (71.6%), 200 CD (26.3%) and 15 unclassifiable IBD (1.9%); 177 patients with IBD (23.3%) presented EIMs, 123 of 544 (22.6%) with UC and 53 of 200 (26.5%) with CD (OR: 0.81, 95% CI: 0.55-1.17, P = 0.31). Regarding the type of EIMs, the articular ones were the most frequent (13.5%), more in CD than in UC (20.0 vs. 11.3%, OR 1.94, 95% CI: 1.25-3.00, P = 0.0037). Patients with IBD and EIMs used more antibodies against tumor necrosis factor (anti-TNFs), compared to those without EIMs (43.5 vs. 18.5%, OR 3.38, 95% CI: 2.31-4.90, P = 0.0001). Conclusions: The prevalence of EIMs in our cohort is high (23.3%) and the most frequent type is joint. Anti-TNFs are most used when IBD and EIMs coexist. Our study provides valuable information on the association of EIMs and IBD in Latin America.

    Título traducido de la contribuciónCharacterization and prevalence of extraintestinal manifestations in a cohort of patients with inflammatory intestinal disease in Medellin, Colombia
    Idioma originalEspañol
    Páginas (desde-hasta)398-404
    Número de páginas7
    PublicaciónGastroenterologia y Hepatologia
    Volumen44
    N.º6
    DOI
    EstadoPublicada - 1 jun. 2021

    Nota bibliográfica

    Publisher Copyright:
    © 2020 Elsevier España, S.L.U.

    Palabras clave

    • Crohn's disease
    • Extraintestinal manifestations
    • Ulcerative colitis

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