Cardiometabolic risk factors in preschool children with abdominal obesity from Medellín, Colombia

Catalina Marín-Echeverri, Juan C. Aristizábal, Natalia Gallego-Lopera, Hugo A. Santa-Ramírez, Marcela Hoyos-Gómez, Adriana Marcela Ruiz-Pineda, Andrés A. Arias, Jacqueline Barona-Acevedo

Producción científica: Contribución a una revistaArtículo en revista científica indexadarevisión exhaustiva

10 Citas (Scopus)

Resumen

Abdominal obesity (AO) is linked to inflammation and insulin resistance (IR). However, there is limited information on whether preschoolers with AO present these risk factors. We evaluated the association between AO and cardiovascular risk factors in preschoolers. We enrolled 232 children (2-5 years), of whom 50% had AO. Serum total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-c), high-density lipoprotein-cholesterol (HDL-c), triglycerides (TG), apolipoprotein B (Apo-B) and apolipoprotein A-1 (Apo-A1), glucose, insulin, high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-α), interleukin (IL)-6, IL-1β, monocyte chemoattractant protein (MCP-1/CCL2), leptin, adiponectin, vascular cell adhesion molecule (VCAM-1/CD106) and intercellular adhesion molecule (ICAM-1/CD54) were measured. The homeostatic model assessment of IR (HOMA-IR) was calculated. We analyzed these variables according to the presence of AO and other metabolic syndrome (MetS) components. A total of 75.8% of children with AO had one or more risk factors for MetS. Children with AO had significantly higher body mass indexes (BMIs), insulin, HOMA-IR, TG, very low-density lipoprotein-cholesterol (VLDL-c) and TC/HDL-c ratio and lower HDL-c, compared to children without AO; but there were no differences in inflammatory markers. After adjusting for BMI, sex and age, the differences between groups were not significant for any variable. Waist circumference (WC) was correlated with insulin (r=0.547; p
Idioma originalEspañol (Colombia)
Páginas (desde-hasta)1179-1189
Número de páginas11
PublicaciónJournal of Pediatric Endocrinology and Metabolism
Volumen31
N.º11
DOI
EstadoPublicada - 26 oct. 2018
Publicado de forma externa

Palabras clave

  • cardiovascular
  • central obesity
  • inflammation
  • insulin resistance
  • metabolic syndrome
  • preschool children

Tipos de Productos Minciencias

  • Artículos de investigación con calidad A2 / Q2

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