COGENT (COlorectal cancer GENeTics) revisited

I. Tomlinson; M. Dunlop; H. Campbell; B. Zanke; S. Gallinger; T. Hudson; T. Koessler; P. D. Pharoah; I. Niittymäki; S. Tuupanen; L. A. Aaltonen; K. Hemminki; A. Lindblom; A. Försti; O. Sieber; L. Lipton; T. van Wezel; H. Morreau; J. T. Wijnen; P. Devilee; K. Matsuda; Y. Nakamura; S. Castellví-Bel; C. Ruiz-Ponte; A. Castells; A. Carracedo; J. W.C. Ho; P. Sham; P. Vodicka; H. Brenner; J. Hampe; C. Schafmayer; J. Tepel; S. Schreiber; H. Völzke; M. M. Lerch; C. A. Schmidt; S. Buch; V. Moreno; C. M. Villanueva; P. Peterlongo; P. Radice; L. Li; M. M. Echeverry; M. Bohorquez; A. Velez; L. Carvajal-Carmona; R. Scott; S. Penegar; P. Broderick; A. Tenesa; R. S. Houlston; Eamonn Maher; Gareth Evans; Lisa Walker; Dorothy Halliday; Anneke Lucassen; Joan Paterson; Shirley Hodgson; Tessa Homfray; Lucy Side; Louise Izatt; Alan Donaldson; Susan Tomkins; Patrick Morrison; Carole Brewer; Alex Henderson; Rosemarie Davidson; Victoria Murday; Jaqueline Cook; Neva Haites; Timothy Bishop; Eamonn Sheridan; Andrew Green; Christopher Marks; Sue Carpenter; Mary Broughton; Surrey Lynn Greenhalge; Mohnish Suri; Juan Diego Morillas; Raquel Muñoz; Marisa Manzano; Francisco Colina; Jose Díaz; Carolina Ibarrola; Guadalupe López; Antoni Castells; Virgínia Piñol; Sergi Castellví-Bel; Francesc Balaguer; Victoria Gonzalo; Teresa Ocaña; María Dolores Giráldez; Maria Pellisé; Anna Serradesanferm; Leticia Moreira; Miriam Cuatrecasas; Josep M. Piqué; Ángel Lanas; Javier Alcedo; Javier Ortego; Joaquin Cubiella; M. Soledad Díez; Mercedes Salgado; Eloy Sánchez; Montserrat Andreu; Anna Abuli; Xavier Bessa; Mar Iglesias; Agustín Seoane; Felipe Bory; Gemma Navarro; Beatriz Bellosillo Josep Mª Dedeu; Cristina Álvarez; Luis Bujanda; Ángel Cosme; Inés Gil; Mikel Larzabal; Carlos Placer; María del Mar Ramírez; Elisabeth Hijona; Jose M. Enríquez-Navascués y Jose L; Artemio Payá; Rodrigo Jover; Cristina Alenda; Laura Sempere; Nuria Acame; Estefanía Rojas; Joaquim Rigau; Ángel Serrano; Anna Giménez; Joan Saló; Eduard Batiste-Alentorn; Josefina Autonell; Ana María García; Fernando Carballo; Antonio Bienvenido; Eduardo Sanz; Fernando González; Jaime Sánchez; Mercedes Latorre; Enrique Medina; Jaime Cuquerella; Pilar Canelles; Miguel Martorell; José Ángel García; Francisco Quiles; Juan Clofent; Jaime Seoane; Antoni Tardío; Eugenia Sanchez; Luisa de Castro; Antoni Tardío; Juan Clofent; Xavier Llor; Rosa M. Xicola; Marta Piñol; Mercè Rosinach; Anna Roca; Elisenda Pons; José M. Hernández; Fernando Fernández-Bañares; Josep M. Viver; Antonio Salas; Jorge Espinós; Josep M. Reñé; Carmen Piñol; Juan Buenestado; Enrique Quintero; David Nicolás; Adolfo Parra; Lidia Argüello; Vicente Pons; Virginia Pertejo; Dolors Gonzalez; Eva Roman; Teresa Ramon; Maria Poca; M. Mar Concepción; Marta Martin; Daniel Martinez; Clara Ruiz-Ponte; Ceres Fernández-Rozadilla; Sabino Riestra; Javier Fernández; Luis Carreño; Susana Oquiñena; Federico Bolado

doi:10.1093/mutage/ger059

COGENT (COlorectal cancer GENeTics) revisited

I. Tomlinson, M. Dunlop, H. Campbell, B. Zanke, S. Gallinger, T. Hudson, T. Koessler, P. D. Pharoah, I. Niittymäki, S. Tuupanen, L. A. Aaltonen, K. Hemminki, A. Lindblom, A. Försti, O. Sieber, L. Lipton, T. van Wezel, H. Morreau, J. T. Wijnen, P. DevileeK. Matsuda, Y. Nakamura, S. Castellví-Bel, C. Ruiz-Ponte, A. Castells, A. Carracedo, J. W.C. Ho, P. Sham, P. Vodicka, H. Brenner, J. Hampe, C. Schafmayer, J. Tepel, S. Schreiber, H. Völzke, M. M. Lerch, C. A. Schmidt, S. Buch, V. Moreno, C. M. Villanueva, P. Peterlongo, P. Radice, L. Li, M. M. Echeverry, M. Bohorquez, A. Velez, L. Carvajal-Carmona, R. Scott, S. Penegar, P. Broderick, A. Tenesa, R. S. Houlston, Eamonn Maher, Gareth Evans, Lisa Walker, Dorothy Halliday, Anneke Lucassen, Joan Paterson, Shirley Hodgson, Tessa Homfray, Lucy Side, Louise Izatt, Alan Donaldson, Susan Tomkins, Patrick Morrison, Carole Brewer, Alex Henderson, Rosemarie Davidson, Victoria Murday, Jaqueline Cook, Neva Haites, Timothy Bishop, Eamonn Sheridan, Andrew Green, Christopher Marks, Sue Carpenter, Mary Broughton, Surrey Lynn Greenhalge, Mohnish Suri, Juan Diego Morillas, Raquel Muñoz, Marisa Manzano, Francisco Colina, Jose Díaz, Carolina Ibarrola, Guadalupe López, Antoni Castells, Virgínia Piñol, Sergi Castellví-Bel, Francesc Balaguer, Victoria Gonzalo, Teresa Ocaña, María Dolores Giráldez, Maria Pellisé, Anna Serradesanferm, Leticia Moreira, Miriam Cuatrecasas, Josep M. Piqué, Ángel Lanas, Javier Alcedo, Javier Ortego, Joaquin Cubiella, M. Soledad Díez, Mercedes Salgado, Eloy Sánchez, Montserrat Andreu, Anna Abuli, Xavier Bessa, Mar Iglesias, Agustín Seoane, Felipe Bory, Gemma Navarro, Beatriz Bellosillo Josep Mª Dedeu, Cristina Álvarez, Luis Bujanda, Ángel Cosme, Inés Gil, Mikel Larzabal, Carlos Placer, María del Mar Ramírez, Elisabeth Hijona, Jose M. Enríquez-Navascués y Jose L, Artemio Payá, Rodrigo Jover, Cristina Alenda, Laura Sempere, Nuria Acame, Estefanía Rojas, Joaquim Rigau, Ángel Serrano, Anna Giménez, Joan Saló, Eduard Batiste-Alentorn, Josefina Autonell, Ana María García, Fernando Carballo, Antonio Bienvenido, Eduardo Sanz, Fernando González, Jaime Sánchez, Mercedes Latorre, Enrique Medina, Jaime Cuquerella, Pilar Canelles, Miguel Martorell, José Ángel García, Francisco Quiles, Juan Clofent, Jaime Seoane, Antoni Tardío, Eugenia Sanchez, Luisa de Castro, Antoni Tardío, Juan Clofent, Xavier Llor, Rosa M. Xicola, Marta Piñol, Mercè Rosinach, Anna Roca, Elisenda Pons, José M. Hernández, Fernando Fernández-Bañares, Josep M. Viver, Antonio Salas, Jorge Espinós, Josep M. Reñé, Carmen Piñol, Juan Buenestado, Enrique Quintero, David Nicolás, Adolfo Parra, Lidia Argüello, Vicente Pons, Virginia Pertejo, Dolors Gonzalez, Eva Roman, Teresa Ramon, Maria Poca, M. Mar Concepción, Marta Martin, Daniel Martinez, Clara Ruiz-Ponte, Ceres Fernández-Rozadilla, Sabino Riestra, Javier Fernández, Luis Carreño, Susana Oquiñena, Federico Bolado

Producción científica: Contribución a una revista › Artículo en revista científica indexada › revisión exhaustiva

26 Citas (Scopus)

Resumen

Many colorectal cancers (CRCs) develop in genetically susceptible individuals most of whom are not carriers of germ line mismatch repair or APC gene mutations and much of the heritable risk of CRC appears to be attributable to the co-inheritance of multiple low-risk variants. The accumulated experience to date in identifying this class of susceptibility allele has highlighted the need to conduct statistically and methodologically rigorous studies and the need for the multi-centre collaboration. This has been the motivation for establishing the COGENT (COlorectal cancer GENeTics) consortium which now includes over 20 research groups in Europe, Australia, the Americas, China and Japan actively working on CRC genetics. Here, we review the rationale for identifying low-penetrance variants for CRC and the current and future challenges for COGENT.

Idioma original	Inglés
Páginas (desde-hasta)	143-151
Número de páginas	9
Publicación	Mutagenesis
Volumen	27
N.º	2
DOI	https://doi.org/10.1093/mutage/ger059
Estado	Publicada - 1 mar. 2012

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Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

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Tomlinson, I., Dunlop, M., Campbell, H., Zanke, B., Gallinger, S., Hudson, T., Koessler, T., Pharoah, P. D., Niittymäki, I., Tuupanen, S., Aaltonen, L. A., Hemminki, K., Lindblom, A., Försti, A., Sieber, O., Lipton, L., van Wezel, T., Morreau, H., Wijnen, J. T., ... Bolado, F. (2012). COGENT (COlorectal cancer GENeTics) revisited. Mutagenesis, 27(2), 143-151. https://doi.org/10.1093/mutage/ger059

@article{97a746214f5341b19a0ad268a58a6a6d,

title = "COGENT (COlorectal cancer GENeTics) revisited",

abstract = "Many colorectal cancers (CRCs) develop in genetically susceptible individuals most of whom are not carriers of germ line mismatch repair or APC gene mutations and much of the heritable risk of CRC appears to be attributable to the co-inheritance of multiple low-risk variants. The accumulated experience to date in identifying this class of susceptibility allele has highlighted the need to conduct statistically and methodologically rigorous studies and the need for the multi-centre collaboration. This has been the motivation for establishing the COGENT (COlorectal cancer GENeTics) consortium which now includes over 20 research groups in Europe, Australia, the Americas, China and Japan actively working on CRC genetics. Here, we review the rationale for identifying low-penetrance variants for CRC and the current and future challenges for COGENT.",

author = "I. Tomlinson and M. Dunlop and H. Campbell and B. Zanke and S. Gallinger and T. Hudson and T. Koessler and Pharoah, {P. D.} and I. Niittym{\"a}ki and S. Tuupanen and Aaltonen, {L. A.} and K. Hemminki and A. Lindblom and A. F{\"o}rsti and O. Sieber and L. Lipton and {van Wezel}, T. and H. Morreau and Wijnen, {J. T.} and P. Devilee and K. Matsuda and Y. Nakamura and S. Castellv{\'i}-Bel and C. Ruiz-Ponte and A. Castells and A. Carracedo and Ho, {J. W.C.} and P. Sham and P. Vodicka and H. Brenner and J. Hampe and C. Schafmayer and J. Tepel and S. Schreiber and H. V{\"o}lzke and Lerch, {M. M.} and Schmidt, {C. A.} and S. Buch and V. Moreno and Villanueva, {C. M.} and P. Peterlongo and P. Radice and L. Li and Echeverry, {M. M.} and M. Bohorquez and A. Velez and L. Carvajal-Carmona and R. Scott and S. Penegar and P. Broderick and A. Tenesa and Houlston, {R. S.} and Eamonn Maher and Gareth Evans and Lisa Walker and Dorothy Halliday and Anneke Lucassen and Joan Paterson and Shirley Hodgson and Tessa Homfray and Lucy Side and Louise Izatt and Alan Donaldson and Susan Tomkins and Patrick Morrison and Carole Brewer and Alex Henderson and Rosemarie Davidson and Victoria Murday and Jaqueline Cook and Neva Haites and Timothy Bishop and Eamonn Sheridan and Andrew Green and Christopher Marks and Sue Carpenter and Mary Broughton and {Lynn Greenhalge}, Surrey and Mohnish Suri and {Diego Morillas}, Juan and Raquel Mu{\~n}oz and Marisa Manzano and Francisco Colina and Jose D{\'i}az and Carolina Ibarrola and Guadalupe L{\'o}pez and Antoni Castells and Virg{\'i}nia Pi{\~n}ol and Sergi Castellv{\'i}-Bel and Francesc Balaguer and Victoria Gonzalo and Teresa Oca{\~n}a and Gir{\'a}ldez, {Mar{\'i}a Dolores} and Maria Pellis{\'e} and Anna Serradesanferm and Leticia Moreira and Miriam Cuatrecasas and Piqu{\'e}, {Josep M.} and {\'A}ngel Lanas and Javier Alcedo and Javier Ortego and Joaquin Cubiella and D{\'i}ez, {M. Soledad} and Mercedes Salgado and Eloy S{\'a}nchez and Montserrat Andreu and Anna Abuli and Xavier Bessa and Mar Iglesias and Agust{\'i}n Seoane and Felipe Bory and Gemma Navarro and {Bellosillo Josep Mª Dedeu}, Beatriz and Cristina {\'A}lvarez and Luis Bujanda and {\'A}ngel Cosme and In{\'e}s Gil and Mikel Larzabal and Carlos Placer and {del Mar Ram{\'i}rez}, Mar{\'i}a and Elisabeth Hijona and {Enr{\'i}quez-Navascu{\'e}s y Jose L}, {Jose M.} and Artemio Pay{\'a} and Rodrigo Jover and Cristina Alenda and Laura Sempere and Nuria Acame and Estefan{\'i}a Rojas and Joaquim Rigau and {\'A}ngel Serrano and Anna Gim{\'e}nez and Joan Sal{\'o} and Eduard Batiste-Alentorn and Josefina Autonell and {Mar{\'i}a Garc{\'i}a}, Ana and Fernando Carballo and Antonio Bienvenido and Eduardo Sanz and Fernando Gonz{\'a}lez and Jaime S{\'a}nchez and Mercedes Latorre and Enrique Medina and Jaime Cuquerella and Pilar Canelles and Miguel Martorell and Garc{\'i}a, {Jos{\'e} {\'A}ngel} and Francisco Quiles and Juan Clofent and Jaime Seoane and Antoni Tard{\'i}o and Eugenia Sanchez and {de Castro}, Luisa and Antoni Tard{\'i}o and Juan Clofent and Xavier Llor and Xicola, {Rosa M.} and Marta Pi{\~n}ol and Merc{\`e} Rosinach and Anna Roca and Elisenda Pons and Hern{\'a}ndez, {Jos{\'e} M.} and Fernando Fern{\'a}ndez-Ba{\~n}ares and Viver, {Josep M.} and Antonio Salas and Jorge Espin{\'o}s and {M. Re{\~n}{\'e}}, Josep and Carmen Pi{\~n}ol and Juan Buenestado and Enrique Quintero and David Nicol{\'a}s and Adolfo Parra and Lidia Arg{\"u}ello and Vicente Pons and Virginia Pertejo and Dolors Gonzalez and Eva Roman and Teresa Ramon and Maria Poca and Concepci{\'o}n, {M. Mar} and Marta Martin and Daniel Martinez and Clara Ruiz-Ponte and Ceres Fern{\'a}ndez-Rozadilla and Sabino Riestra and Javier Fern{\'a}ndez and Luis Carre{\~n}o and Susana Oqui{\~n}ena and Federico Bolado",

year = "2012",

month = mar,

day = "1",

doi = "10.1093/mutage/ger059",

language = "Ingl{\'e}s",

volume = "27",

pages = "143--151",

journal = "Mutagenesis",

issn = "0267-8357",

publisher = "Oxford University Press",

number = "2",

}

Tomlinson, I, Dunlop, M, Campbell, H, Zanke, B, Gallinger, S, Hudson, T, Koessler, T, Pharoah, PD, Niittymäki, I, Tuupanen, S, Aaltonen, LA, Hemminki, K, Lindblom, A, Försti, A, Sieber, O, Lipton, L, van Wezel, T, Morreau, H, Wijnen, JT, Devilee, P, Matsuda, K, Nakamura, Y, Castellví-Bel, S, Ruiz-Ponte, C, Castells, A, Carracedo, A, Ho, JWC, Sham, P, Vodicka, P, Brenner, H, Hampe, J, Schafmayer, C, Tepel, J, Schreiber, S, Völzke, H, Lerch, MM, Schmidt, CA, Buch, S, Moreno, V, Villanueva, CM, Peterlongo, P, Radice, P, Li, L, Echeverry, MM, Bohorquez, M, Velez, A, Carvajal-Carmona, L, Scott, R, Penegar, S, Broderick, P, Tenesa, A, Houlston, RS, Maher, E, Evans, G, Walker, L, Halliday, D, Lucassen, A, Paterson, J, Hodgson, S, Homfray, T, Side, L, Izatt, L, Donaldson, A, Tomkins, S, Morrison, P, Brewer, C, Henderson, A, Davidson, R, Murday, V, Cook, J, Haites, N, Bishop, T, Sheridan, E, Green, A, Marks, C, Carpenter, S, Broughton, M, Lynn Greenhalge, S, Suri, M, Diego Morillas, J, Muñoz, R, Manzano, M, Colina, F, Díaz, J, Ibarrola, C, López, G, Castells, A, Piñol, V, Castellví-Bel, S, Balaguer, F, Gonzalo, V, Ocaña, T, Giráldez, MD, Pellisé, M, Serradesanferm, A, Moreira, L, Cuatrecasas, M, Piqué, JM, Lanas, Á, Alcedo, J, Ortego, J, Cubiella, J, Díez, MS, Salgado, M, Sánchez, E, Andreu, M, Abuli, A, Bessa, X, Iglesias, M, Seoane, A, Bory, F, Navarro, G, Bellosillo Josep Mª Dedeu, B, Álvarez, C, Bujanda, L, Cosme, Á, Gil, I, Larzabal, M, Placer, C, del Mar Ramírez, M, Hijona, E, Enríquez-Navascués y Jose L, JM, Payá, A, Jover, R, Alenda, C, Sempere, L, Acame, N, Rojas, E, Rigau, J, Serrano, Á, Giménez, A, Saló, J, Batiste-Alentorn, E, Autonell, J, María García, A, Carballo, F, Bienvenido, A, Sanz, E, González, F, Sánchez, J, Latorre, M, Medina, E, Cuquerella, J, Canelles, P, Martorell, M, García, JÁ, Quiles, F, Clofent, J, Seoane, J, Tardío, A, Sanchez, E, de Castro, L, Tardío, A, Clofent, J, Llor, X, Xicola, RM, Piñol, M, Rosinach, M, Roca, A, Pons, E, Hernández, JM, Fernández-Bañares, F, Viver, JM, Salas, A, Espinós, J, M. Reñé, J, Piñol, C, Buenestado, J, Quintero, E, Nicolás, D, Parra, A, Argüello, L, Pons, V, Pertejo, V, Gonzalez, D, Roman, E, Ramon, T, Poca, M, Concepción, MM, Martin, M, Martinez, D, Ruiz-Ponte, C, Fernández-Rozadilla, C, Riestra, S, Fernández, J, Carreño, L, Oquiñena, S & Bolado, F 2012, 'COGENT (COlorectal cancer GENeTics) revisited', Mutagenesis, vol. 27, n.º 2, pp. 143-151. https://doi.org/10.1093/mutage/ger059

TY - JOUR

T1 - COGENT (COlorectal cancer GENeTics) revisited

AU - Tomlinson, I.

AU - Dunlop, M.

AU - Campbell, H.

AU - Zanke, B.

AU - Gallinger, S.

AU - Hudson, T.

AU - Koessler, T.

AU - Pharoah, P. D.

AU - Niittymäki, I.

AU - Tuupanen, S.

AU - Aaltonen, L. A.

AU - Hemminki, K.

AU - Lindblom, A.

AU - Försti, A.

AU - Sieber, O.

AU - Lipton, L.

AU - van Wezel, T.

AU - Morreau, H.

AU - Wijnen, J. T.

AU - Devilee, P.

AU - Matsuda, K.

AU - Nakamura, Y.

AU - Castellví-Bel, S.

AU - Ruiz-Ponte, C.

AU - Castells, A.

AU - Carracedo, A.

AU - Ho, J. W.C.

AU - Sham, P.

AU - Vodicka, P.

AU - Brenner, H.

AU - Hampe, J.

AU - Schafmayer, C.

AU - Tepel, J.

AU - Schreiber, S.

AU - Völzke, H.

AU - Lerch, M. M.

AU - Schmidt, C. A.

AU - Buch, S.

AU - Moreno, V.

AU - Villanueva, C. M.

AU - Peterlongo, P.

AU - Radice, P.

AU - Li, L.

AU - Echeverry, M. M.

AU - Bohorquez, M.

AU - Velez, A.

AU - Carvajal-Carmona, L.

AU - Scott, R.

AU - Penegar, S.

AU - Broderick, P.

AU - Tenesa, A.

AU - Houlston, R. S.

AU - Maher, Eamonn

AU - Evans, Gareth

AU - Walker, Lisa

AU - Halliday, Dorothy

AU - Lucassen, Anneke

AU - Paterson, Joan

AU - Hodgson, Shirley

AU - Homfray, Tessa

AU - Side, Lucy

AU - Izatt, Louise

AU - Donaldson, Alan

AU - Tomkins, Susan

AU - Morrison, Patrick

AU - Brewer, Carole

AU - Henderson, Alex

AU - Davidson, Rosemarie

AU - Murday, Victoria

AU - Cook, Jaqueline

AU - Haites, Neva

AU - Bishop, Timothy

AU - Sheridan, Eamonn

AU - Green, Andrew

AU - Marks, Christopher

AU - Carpenter, Sue

AU - Broughton, Mary

AU - Lynn Greenhalge, Surrey

AU - Suri, Mohnish

AU - Diego Morillas, Juan

AU - Muñoz, Raquel

AU - Manzano, Marisa

AU - Colina, Francisco

AU - Díaz, Jose

AU - Ibarrola, Carolina

AU - López, Guadalupe

AU - Castells, Antoni

AU - Piñol, Virgínia

AU - Castellví-Bel, Sergi

AU - Balaguer, Francesc

AU - Gonzalo, Victoria

AU - Ocaña, Teresa

AU - Giráldez, María Dolores

AU - Pellisé, Maria

AU - Serradesanferm, Anna

AU - Moreira, Leticia

AU - Cuatrecasas, Miriam

AU - Piqué, Josep M.

AU - Lanas, Ángel

AU - Alcedo, Javier

AU - Ortego, Javier

AU - Cubiella, Joaquin

AU - Díez, M. Soledad

AU - Salgado, Mercedes

AU - Sánchez, Eloy

AU - Andreu, Montserrat

AU - Abuli, Anna

AU - Bessa, Xavier

AU - Iglesias, Mar

AU - Seoane, Agustín

AU - Bory, Felipe

AU - Navarro, Gemma

AU - Bellosillo Josep Mª Dedeu, Beatriz

AU - Álvarez, Cristina

AU - Bujanda, Luis

AU - Cosme, Ángel

AU - Gil, Inés

AU - Larzabal, Mikel

AU - Placer, Carlos

AU - del Mar Ramírez, María

AU - Hijona, Elisabeth

AU - Enríquez-Navascués y Jose L, Jose M.

AU - Payá, Artemio

AU - Jover, Rodrigo

AU - Alenda, Cristina

AU - Sempere, Laura

AU - Acame, Nuria

AU - Rojas, Estefanía

AU - Rigau, Joaquim

AU - Serrano, Ángel

AU - Giménez, Anna

AU - Saló, Joan

AU - Batiste-Alentorn, Eduard

AU - Autonell, Josefina

AU - María García, Ana

AU - Carballo, Fernando

AU - Bienvenido, Antonio

AU - Sanz, Eduardo

AU - González, Fernando

AU - Sánchez, Jaime

AU - Latorre, Mercedes

AU - Medina, Enrique

AU - Cuquerella, Jaime

AU - Canelles, Pilar

AU - Martorell, Miguel

AU - García, José Ángel

AU - Quiles, Francisco

AU - Clofent, Juan

AU - Seoane, Jaime

AU - Tardío, Antoni

AU - Sanchez, Eugenia

AU - de Castro, Luisa

AU - Tardío, Antoni

AU - Clofent, Juan

AU - Llor, Xavier

AU - Xicola, Rosa M.

AU - Piñol, Marta

AU - Rosinach, Mercè

AU - Roca, Anna

AU - Pons, Elisenda

AU - Hernández, José M.

AU - Fernández-Bañares, Fernando

AU - Viver, Josep M.

AU - Salas, Antonio

AU - Espinós, Jorge

AU - M. Reñé, Josep

AU - Piñol, Carmen

AU - Buenestado, Juan

AU - Quintero, Enrique

AU - Nicolás, David

AU - Parra, Adolfo

AU - Argüello, Lidia

AU - Pons, Vicente

AU - Pertejo, Virginia

AU - Gonzalez, Dolors

AU - Roman, Eva

AU - Ramon, Teresa

AU - Poca, Maria

AU - Concepción, M. Mar

AU - Martin, Marta

AU - Martinez, Daniel

AU - Ruiz-Ponte, Clara

AU - Fernández-Rozadilla, Ceres

AU - Riestra, Sabino

AU - Fernández, Javier

AU - Carreño, Luis

AU - Oquiñena, Susana

AU - Bolado, Federico

PY - 2012/3/1

Y1 - 2012/3/1

N2 - Many colorectal cancers (CRCs) develop in genetically susceptible individuals most of whom are not carriers of germ line mismatch repair or APC gene mutations and much of the heritable risk of CRC appears to be attributable to the co-inheritance of multiple low-risk variants. The accumulated experience to date in identifying this class of susceptibility allele has highlighted the need to conduct statistically and methodologically rigorous studies and the need for the multi-centre collaboration. This has been the motivation for establishing the COGENT (COlorectal cancer GENeTics) consortium which now includes over 20 research groups in Europe, Australia, the Americas, China and Japan actively working on CRC genetics. Here, we review the rationale for identifying low-penetrance variants for CRC and the current and future challenges for COGENT.

AB - Many colorectal cancers (CRCs) develop in genetically susceptible individuals most of whom are not carriers of germ line mismatch repair or APC gene mutations and much of the heritable risk of CRC appears to be attributable to the co-inheritance of multiple low-risk variants. The accumulated experience to date in identifying this class of susceptibility allele has highlighted the need to conduct statistically and methodologically rigorous studies and the need for the multi-centre collaboration. This has been the motivation for establishing the COGENT (COlorectal cancer GENeTics) consortium which now includes over 20 research groups in Europe, Australia, the Americas, China and Japan actively working on CRC genetics. Here, we review the rationale for identifying low-penetrance variants for CRC and the current and future challenges for COGENT.

UR - http://www.scopus.com/inward/record.url?scp=84856944802&partnerID=8YFLogxK

U2 - 10.1093/mutage/ger059

DO - 10.1093/mutage/ger059

M3 - Artículo en revista científica indexada

C2 - 22294761

AN - SCOPUS:84856944802

SN - 0267-8357

VL - 27

SP - 143

EP - 151

JO - Mutagenesis

JF - Mutagenesis

IS - 2

ER -

COGENT (COlorectal cancer GENeTics) revisited

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