Cognitive performance in asymptomatic carriers of mutations R1031C and R141C in CADASIL

Yesica Zuluaga-Castaño, David Andrés Montoya-Arenas, Lina Velilla, Carolina Ospina, Joseph F. Arboleda-Velasquez, Yakeel T. Quiroz, Francisco Lopera

    Producción científica: Contribución a una revistaArtículo en revista científica indexadarevisión exhaustiva

    4 Citas (Scopus)

    Resumen

    CADASIL is the most common hereditary cause of repeated ischemic strokes, and has also been identified as a model of pure vascular dementia. The objective of this study was to establish the cognitive performance of asymptomatic carriers with the mutations R1031C and R141C. This observational cross-sectional analytical study divided subjects into three groups: asymptomatic carriers of the R1031C mutation (n = 39), asymptomatic carries of the R141C mutation (n = 8) and non-carriers (n = 50). Statistically significant differences were found (n < 0.05) between the group of the R1031C mutation and the non-carriers in constructional praxis, executive function and abstract reasoning. For the R141C mutation, scores below expected values in executive function and mental calculation were observed. It is concluded that asymptomatic carriers of the two mutations showed low performance in working memory, mental abstraction and processing speed, which could be associated with preclinical cognitive biomarkers preceding the presentation of the first vascular event.

    Idioma originalInglés
    Páginas (desde-hasta)46-55
    Número de páginas10
    PublicaciónInternational Journal of Psychological Research
    Volumen11
    N.º2
    DOI
    EstadoPublicada - 2018

    Nota bibliográfica

    Publisher Copyright:
    © 2018 Universidad San Buenaventura. All rights reserved.

    Tipos de Productos Minciencias

    • Artículos de investigación con calidad Q4

    Huella

    Profundice en los temas de investigación de 'Cognitive performance in asymptomatic carriers of mutations R1031C and R141C in CADASIL'. En conjunto forman una huella única.

    Citar esto