Combined Use of Gastric Aspirate and Induced Sputum Increases the Microbiological Diagnosis of Tuberculosis in Children

Santiago Atehortua-Munoz, Andrea Cardona-Moreno, Laura Nino-Quiroga, Javier Contreras-Ortiz, Catalina Arango-Ferreira

Producción científica: Contribución a una revistaArtículo en revista científica indexadarevisión exhaustiva

2 Citas (Scopus)

Resumen

Objective  Diagnosis of pulmonary tuberculosis (PTB) in pediatrics is a challenge due to the paucibacillary condition of the disease in this population, low sputum expectoration, and diverse unspecific symptomatology. Mycobacterial isolation through culture remains a priority. The objective of this study is to explore gastric aspirates and induced sputum techniques in the pediatric population for positivity on mycobacterial cultures. Methods  In this observational analytical study, two temporal groups were evaluated. A comparison of the isolation rate defined as positive culture confirmation by gastric aspirate (GA), induced sputum (IS), or combination of these both techniques in children under 10 years of age. The study included 86 children, 37 in the first evaluated study group and 49 in the second group. Discussion  Culture positivity was 10.8 and 30.6% for the first and second case series, respectively. These findings showed that the combination of GA and IS in two consecutive days yielded a significantly higher detection rate to confirm pulmonary tuberculosis by culture. Conclusion  The combination of GA plus IS samples for collection of M. tuberculosis culture can be a useful, nonexpensive, and safe diagnostic tool in low- and middleincome countries to diagnose tuberculosis in children.
Idioma originalEspañol (Colombia)
Páginas (desde-hasta)217-222
Número de páginas6
PublicaciónJournal of Pediatric Infectious Diseases
Volumen15
N.º5
DOI
EstadoPublicada - 21 abr. 2020
Publicado de forma externa

Palabras clave

  • child
  • gastric aspirate
  • induced sputum
  • pulmonary tuberculosis

Tipos de Productos Minciencias

  • Artículos de investigación con calidad A1 / Q1

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