Computational modelling of the behaviour of biomarker particles of colorectal cancer in fecal matter

G. Suárez, E. Vallejo, L. Hoyos

    Resultado de la investigación: Capítulo del libro/informe/acta de congresoContribución a la conferenciarevisión exhaustiva

    1 Cita (Scopus)

    Resumen

    Colorectal adenocarcinoma is one of the carcinogenic diseases that is increasing the morbidity and mortality rates worldwide. The disease initially occurs through the segregation of biomarker substances in the human system without manifesting symptoms that affect the health of the carrier. Early detection would allow the application of more effective treatments, less invasive procedures and reduce the development of cancer. The purpose of this investigation was the elaboration of a mathematical model and the development of computational simulations to visualize the behavior of biomarker particles in transit through the colon. The flow conditions, properties of the viscous medium and biological regions of interest were established. Constitutive models, numerical conditions and solution strategies were determined. A numerical grid was used to represent the model of the colon and the human feces that carry the bioparticles (biomarkers). The results indicated the trajectories of the bioparticles in the fecal mass and the interactive movement with the natural contractions of the colon. The analysis of the movement of the biomarker particles can provide future less invasive alternatives for the detection in real time of the cancer by means of the implantation of biosensors in the walls of the colon.

    Idioma originalInglés
    Título de la publicación alojada15th International Conference on Computational Plasticity. Fundamentals and Applications, COMPLAS 2019
    EditoresEugenio Onate, D. Roger J. Owen, Djordje Peric, Michele Chiumenti, Eduardo de Souza Neto
    EditorialInternational Center for Numerical Methods in Engineering
    Páginas334-342
    Número de páginas9
    ISBN (versión digital)9788494919473
    EstadoPublicada - 2019
    Evento15th International Conference on Computational Plasticity. Fundamentals and Applications, COMPLAS 2019 - Barcelona, Espana
    Duración: 3 sept. 20195 sept. 2019

    Serie de la publicación

    Nombre15th International Conference on Computational Plasticity. Fundamentals and Applications, COMPLAS 2019

    Conferencia

    Conferencia15th International Conference on Computational Plasticity. Fundamentals and Applications, COMPLAS 2019
    País/TerritorioEspana
    CiudadBarcelona
    Período3/09/195/09/19

    Nota bibliográfica

    Publisher Copyright:
    Copyright © COMPLAS 2019.

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