Colorectal adenocarcinoma is one of the carcinogenic diseases that is increasing the morbidity and mortality rates worldwide. The disease initially occurs through the segregation of biomarker substances in the human system without manifesting symptoms that affect the health of the carrier. Early detection would allow the application of more effective treatments, less invasive procedures and reduce the development of cancer. The purpose of this investigation was the elaboration of a mathematical model and the development of computational simulations to visualize the behavior of biomarker particles in transit through the colon. The flow conditions, properties of the viscous medium and biological regions of interest were established. Constitutive models, numerical conditions and solution strategies were determined. A numerical grid was used to represent the model of the colon and the human feces that carry the bioparticles (biomarkers). The results indicated the trajectories of the bioparticles in the fecal mass and the interactive movement with the natural contractions of the colon. The analysis of the movement of the biomarker particles can provide future less invasive alternatives for the detection in real time of the cancer by means of the implantation of biosensors in the walls of the colon.
|Título de la publicación alojada||15th International Conference on Computational Plasticity. Fundamentals and Applications, COMPLAS 2019|
|Editores||Eugenio Onate, D. Roger J. Owen, Djordje Peric, Michele Chiumenti, Eduardo de Souza Neto|
|Editorial||International Center for Numerical Methods in Engineering|
|Número de páginas||9|
|ISBN (versión digital)||9788494919473|
|Estado||Publicada - 2019|
|Evento||15th International Conference on Computational Plasticity. Fundamentals and Applications, COMPLAS 2019 - Barcelona, Espana|
Duración: 3 sept. 2019 → 5 sept. 2019
Serie de la publicación
|Nombre||15th International Conference on Computational Plasticity. Fundamentals and Applications, COMPLAS 2019|
|Conferencia||15th International Conference on Computational Plasticity. Fundamentals and Applications, COMPLAS 2019|
|Período||3/09/19 → 5/09/19|
Nota bibliográficaPublisher Copyright:
Copyright © COMPLAS 2019.