Conspicuous multidrug-resistant Mycobacterium tuberculosis cluster strains do not trespass country borders in Latin America and Spain

Viviana Ritacco, María José Iglesias, Lucilaine Ferrazoli, Johana Monteserin, Elis R. Dalla Costa, Alberto Cebollada, Nora Morcillo, Jaime Robledo, Jacobus H. de Waard, Pamela Araya, Liselotte Aristimuño, Raúl Díaz, Patricia Gavin, Belen Imperiale, Vera Simonsen, Elsa M. Zapata, María S. Jiménez, Maria L. Rossetti, Carlos Martin, Lucía BarreraSofia Samper

Producción científica: Contribución a una revistaArtículo en revista científica indexadarevisión exhaustiva

27 Citas (Scopus)


Multidrug-resistant Mycobacterium tuberculosis strain diversity in Ibero-America was examined by comparing extant genotype collections in national or state tuberculosis networks. To this end, genotypes from over 1000 patients with multidrug-resistant tuberculosis diagnosed from 2004 through 2008 in Argentina, Brazil, Chile, Colombia, Venezuela and Spain were compared in a database constructed ad hoc. Most of the 116 clusters identified by IS6110 restriction fragment length polymorphism were small and restricted to individual countries. The three largest clusters, of 116, 49 and 25 patients, were found in Argentina and corresponded to previously documented locally-epidemic strains. Only 13 small clusters involved more than one country, altogether accounting for 41 patients, of whom 13 were, in turn, immigrants from Latin American countries different from those participating in the study (Peru, Ecuador and Bolivia). Most of these international clusters belonged either to the emerging RD Rio LAM lineage or to the Haarlem family of M. tuberculosis and four were further split by country when analyzed with spoligotyping and rifampin resistance-conferring mutations, suggesting that they did not represent ongoing transnational transmission events. The Beijing genotype accounted for 1.3% and 10.2% of patients with multidrug-resistant tuberculosis in Latin America and Spain, respectively, including one international cluster of two cases. In brief, Euro-American genotypes were widely predominant among multidrug-resistant M. tuberculosis strains in Ibero-America, reflecting closely their predominance in the general M. tuberculosis population in the region, and no evidence was found of acknowledged outbreak strains trespassing country borders.

Idioma originalInglés
Páginas (desde-hasta)711-717
Número de páginas7
PublicaciónInfection, Genetics and Evolution
EstadoPublicada - jun. 2012
Publicado de forma externa


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