Cross-linking Effect in Bovine Gelatin and PCL Scaffolds Prepared by Sequential Electrospinning and Co-electrospinning for Potential Use as Vascular Grafts

J. Cardenas, Y. Montoya, J. Bustamante, R. Valencia

    Producción científica: Capítulo del libro/informe/acta de congresoPonencia publicada en las memorias del evento con ISBNrevisión exhaustiva

    Resumen

    Vascular replacement for vessels with diameter smaller than 6 mm prepared with non-biodegradable polymers present complications due to their low biocompatibility, leading to thrombotic occlusion and intimal hyperplasia. Currently, biodegradable polymeric materials of synthetic and natural origin are an alternative for the design of porous walls that provide a biological microenvironment that facilitates the development of a new tissue. Among these polymers, bovine gelatin, derived from the hydrolysis of collagen, is low cost protein which guarantees an adequate biocompatibility. Nevertheless, due to its low resistance in aqueous environments, chemical treatments are required to improve its resistance. Furthermore, glutaraldehyde (GA) cross-linking is widely used because of its high efficiency and low cost. In this study was evaluated the effect of cross-linking by GA on membranes composed of bovine gelatin and polycaprolactone (PCL), prepared by sequential electrospinning and co-electrospinning. Morphological characteristics were observed through scanning electron microscopy (SEM), wettability was determined with contact angle and strength of tubular scaffolds were circumferentially tested. The results showed that the cross-linking had a higher effect on the scaffolds that are obtained by sequential electrospinning compared to co-electrospinning due to the exposure of the bovine gelatin in each type of method.

    Idioma originalInglés
    Título de la publicación alojada2019 Global Medical Engineering Physics Exchanges/ Pan American Health Care Exchanges, GMEPE/PAHCE 2019
    EditorialIEEE Computer Society
    ISBN (versión digital)9781728100357
    DOI
    EstadoPublicada - 16 may. 2019
    Evento2019 Global Medical Engineering Physics Exchanges/ Pan American Health Care Exchanges, GMEPE/PAHCE 2019 - Buenos Aires, Argentina
    Duración: 26 mar. 201931 mar. 2019

    Serie de la publicación

    NombrePan American Health Care Exchanges, PAHCE
    Volumen2019-March
    ISSN (versión impresa)2327-8161
    ISSN (versión digital)2327-817X

    Conferencia

    Conferencia2019 Global Medical Engineering Physics Exchanges/ Pan American Health Care Exchanges, GMEPE/PAHCE 2019
    País/TerritorioArgentina
    CiudadBuenos Aires
    Período26/03/1931/03/19

    Nota bibliográfica

    Publisher Copyright:
    © 2019 IEEE.

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