Development of a novel silk sericin-based hydrogel film by mixture design

Natalia Jaramillo-Quiceno, Santiago Rueda-Mira, Juan Felipe Santa Marín, Catalina Álvarez-López

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6 Citas (Scopus)


Sericin has been used in functional and potentially biodegradable materials for cosmetics, biomedical, agricultural, and food applications. It is a natural polymer with applications in absorbent materials, such as hydrogels, because of its hydrophilic character. However, sericin by itself is brittle, and in contact with water has low structural stability, being necessary its blending with other polymers or the application of crosslinking processes. In this work, hydrogel films were prepared from different mixtures containing sericin (SS), carboxymethylcellulose (CMC), and polyvinyl alcohol (PVA), using a simple and environmentally friendly method consisting of a gelling process followed by solvent casting. A mixture design was applied to assess the incidence of each component and its interaction with the output variables of interest. Two response variables were evaluated in each formulation: water absorption capacity (WA) and gel fraction (GF). It was also possible to model the output variables based on the proportions of the sample components. In addition, a set of formulations were used to produce hydrogels with high water absorption rates while maintaining their structural stability. The optimal hydrogel formulation (HF) was structurally and thermally characterized by FTIR and TGA, respectively. Hydrogel morphology was also studied by scanning electron microscopy (SEM). The results of this study constitute an important contribution to the design of novel processing routes to extend the use of silk sericin in the development of new materials.

Idioma originalInglés
Número de artículo120
PublicaciónJournal of Polymer Research
EstadoPublicada - mar. 2023

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