Efectividad clínica del tratamiento con antifúngicos tópicos en onicomicosis

Luisa Fernanda Ríos-Barco, Luz Marina Gómez-Vargas, Juan Guillermo Barrientos-Gómez, Laura Becerra-Ruiz, Yerlin Andrés Colina-Vargas

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

Resumen

BACKGROUND: Onychomycosis is the infection of the nails by fungi, dermatophytes, yeasts or non-dermatophyte molds. It is associated with a high rate of therapeutic failure (20-50%) due to resistance to different therapeutic agents. OBJECTIVE: To perform a systematic review of the literature to establish the clinical effectiveness of topical antifungals to treat onychomycosis. METHOD: A systematic review of the literature was carried out; original articles were included in English, Spanish and Portuguese, between 1999 and 2016, in five indexed databases. RESULTS: Eight studies were included, classified with a low and indeterminate risk of biases, and a quantitative summary of the results was made: the clinical effectiveness was higher in the 8% water soluble cyclopiroxolamin group vs the 5% amorolfine group with a duration of treatment between 9 and 12 months), as well as in the group of 10% topical efinaconazole solution vs placebo whose treatment time was 12 months and in the group of tavaborole topical solution at 5% vs placebo for 12 months. CONCLUSIONS: When the lamina is less than 60% compromised, in patients without immunosuppression, 8% water soluble cyclopiroxolamin lacquer is superior to 5% amorolfine lacquer, and efinaconazole solution at 10% and tavaborole topical solution at 5% are superior to placebo; however, the complete cure rates found were not greater than 40% in any study, during a maximum treatment time of 12 months.

Título traducido de la contribuciónClinical effectiveness of topical antifungal treatment in onychomycosis
Idioma originalAlemán
Páginas (desde-hasta)270-286
Número de páginas17
PublicaciónDermatologia Revista Mexicana
Volumen64
N.º3
EstadoPublicada - 1 may. 2020
Publicado de forma externa

Nota bibliográfica

Publisher Copyright:
© 2020 Comunicaciones Cientificas Mexicanas S.A. de C.V.. All rights reserved.

Huella

Profundice en los temas de investigación de 'Efectividad clínica del tratamiento con antifúngicos tópicos en onicomicosis'. En conjunto forman una huella única.

Citar esto