El bicarbonato de sodio en comparación con solución salina isotónica para prevenir la nefropatía inducida por contraste: Una revisión sistemática y meta-análisis

Carlos Andres Zapata-Chica, Marquez Diana Bello, Lina Maria Serna-Higuita, John Fredy Nieto-Ríos, Fabian David Casas-Arroyave, Jorge Hernando Donado-Gómez

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

10 Citas (Scopus)

Resumen

Introduction: Contrast-induced nephropathy is one of the main causes of acute kidney injury and increased hospital-acquired morbidity and mortality. The use of sodium bicarbonate for nephroprotection has emerged as a preventative strategy; however, its efficacy is controversial compared to other strategies, such as hydration using 0.9% saline solution. Objective: To compare the effectiveness of sodium bicarbonate vs. hydration using 0.9% saline solution to prevent contrast-induced acute kidney injury. Methods: A systematic review of studies registered in the COCHRANE, PUBMED, MEDLINE, LILACS, SCIELO and EMBASE databases was conducted. Randomized controlled studies that evaluated the use of 0.9% saline solution vs. sodium bicarbonate to prevent contrast-induced nephropathy were included. Results: A total of 22 studies (5,686 patients) were included. Sodium bicarbonate did not decrease the risk of contrast-induced nephropathy (RD= 0.00; 95% CI= -0.02 to 0.03; p= 0.83; I2= 0%). No significant differences were found in the demand for renal replacement therapy (RD= 0.00; 95% CI= -0.01 to 0-01; I2= 0%; p= 0.99) or in mortality (RD= -0.00; 95% CI= -0.001 to 0.001; I2= 0%; p= 0.51). Conclusions: Sodium bicarbonate administration is not superior to the use of 0.9% saline solution for preventing contrast-induced nephropathy in patients with risk factors, nor is it better at reducing mortality or the need for renal replacement therapy.

Título traducido de la contribuciónSodium bicarbonate versus isotonic saline solution to prevent contrast-induced nephropathy: A systematic review and meta-analysis
Idioma originalEspañol
Páginas (desde-hasta)97-108
Número de páginas12
PublicaciónColombia Medica
Volumen46
N.º3
EstadoPublicada - jul. 2015
Publicado de forma externa

Nota bibliográfica

Publisher Copyright:
© 2015. Universidad del Valle.

Palabras clave

  • Acute kidney injury
  • Contrast induced nephropathy
  • Sodium bicarbonate
  • Sodium chloride

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