Electrospinning of collagen with nanocapsules of PLGA for delivery of Paclitaxel in drug-eluting stents

Liliana Maria Agudelo, Jesus Antonio Carlos Cornelio, Luis Fernando Rodriguez, Isabel Cristina Ortiz, Lina Marcela Hoyos, Gabriel Jaime Colmenares

Resultado de la investigación: Capítulo del libro/informe/acta de congresoContribución a la conferenciarevisión exhaustiva

Resumen

This work develops a new delivery system trying to understand better, the factors that influences the drug release. This system use nanofiber produced by electrospinning technic and bioabsorbable polymeric nanocapsules produced by the nanoprecipitation processes in a recirculated system develop in the research group. For this work, we used an electrospinning equipment built at the university, in which you can control the process parameters such as voltage, deposition rate, collector distance, speed and direction of rotation of the collector, to control the morphology and diameter of the nanofibers. The final electrospinning condition to obtain nanofiber of collagen (Sigma-Aldrich) with 99 ± 26 nm was 18 V, collector distance of 14cm, flow rate of 0.1mL/h and polymer concentration was 25% W/V in acetic acid and distilled water 9:1. On the other hand, we encapsulated Paclitaxel in bioabsorbible polymeric nanocapsules of PLGA (Resomer 752 H, Evonik) produced in a recirculated system design in the university. The conditions used to encapsulate the paclitaxel was 4mg/mL of polymer concertation, 20% of drug respect to dry polymer, 162 mL/min of flow rate in the recirculating system, 0.25% of Pluronic F-127 (Sigma-Aldrich) as surfactant in the aqueous phase and 2:1 ratio between aqueous phase and organic phase.

Idioma originalInglés
Título de la publicación alojadaTechConnect Briefs 2018 - Biotech, Biomaterials and Biomedical
EditoresBart Romanowicz, Fiona Case, Fiona Case, Matthew Laudon
EditorialTechConnect
Páginas37-39
Número de páginas3
ISBN (versión digital)9780998878249
EstadoPublicada - 2018
Publicado de forma externa
Evento11th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 20th Annual Nanotech Conference and Expo,the 2018 SBIR/STTR Spring Innovation Conference, and the Defense TechConnect DTC Spring Conference - Anaheim, Estados Unidos
Duración: 13 may. 201816 may. 2018

Serie de la publicación

NombreTechConnect Briefs 2018 - Advanced Materials
Volumen3

Conferencia

Conferencia11th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 20th Annual Nanotech Conference and Expo,the 2018 SBIR/STTR Spring Innovation Conference, and the Defense TechConnect DTC Spring Conference
País/TerritorioEstados Unidos
CiudadAnaheim
Período13/05/1816/05/18

Nota bibliográfica

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