Ertapenem resistance in 2 tertiary-care hospitals: Microbiology, epidemiology, and risk factors

Natalia Maldonado; Bibiana Castro; Indira Berrio; Miguel Manjarrés; Carlos Robledo; Jaime Robledo

doi:10.1016/j.eimc.2015.11.009

Ertapenem resistance in 2 tertiary-care hospitals: Microbiology, epidemiology, and risk factors

Título traducido de la contribución: Resistencia a ertapenem en 2 instituciones hospitalarias de alto nivel de complejidad: microbiología, epidemiología y factores de riesgo

Natalia Maldonado, Bibiana Castro, Indira Berrio, Miguel Manjarrés, Carlos Robledo, Jaime Robledo

Producción científica: Contribución a una revista › Artículo en revista científica indexada › revisión exhaustiva

4 Citas (Scopus)

Resumen

Introduction Carbapenems resistance is a growing phenomenon and a threat to public health because of the reduced therapeutic options for resistant infections. Methods A retrospective case-control study was conducted in 2 tertiary-care hospitals in Medellín, Colombia. Fifty patients infected with ertapenem-resistant enterobacteriaceae were compared with a control group consisting of 100 patients with infections caused by ertapenem susceptible enterobacteriaceae. A multivariate logistic regression model was used to identify factors that best explain ertapenem-resistant enterobacteriaceae infections. Results The factors associated with ertapenem-resistant enterobacteriaceae infections were prior exposure to carbapenems (adjusted OR 3.43; 95% IC 1.08-10.87) and prior exposure to cefepime (adjusted OR 6.46; 95% IC 1.08-38.38). Conclusion Prior exposure to antibiotics is the factor that best explains the ertapenem-resistant enterobacteriaceae infection in this population, highlighting the importance of antimicrobial stewardship programs in hospitals.

Título traducido de la contribución	Resistencia a ertapenem en 2 instituciones hospitalarias de alto nivel de complejidad: microbiología, epidemiología y factores de riesgo
Idioma original	Inglés
Páginas (desde-hasta)	511-515
Número de páginas	5
Publicación	Enfermedades Infecciosas y Microbiologia Clinica
Volumen	35
N.º	8
DOI	https://doi.org/10.1016/j.eimc.2015.11.009
Estado	Publicada - oct. 2017

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© 2015 Elsevier España, S.L.U. y Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica

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title = "Ertapenem resistance in 2 tertiary-care hospitals: Microbiology, epidemiology, and risk factors",

abstract = "Introduction Carbapenems resistance is a growing phenomenon and a threat to public health because of the reduced therapeutic options for resistant infections. Methods A retrospective case-control study was conducted in 2 tertiary-care hospitals in Medell{\'i}n, Colombia. Fifty patients infected with ertapenem-resistant enterobacteriaceae were compared with a control group consisting of 100 patients with infections caused by ertapenem susceptible enterobacteriaceae. A multivariate logistic regression model was used to identify factors that best explain ertapenem-resistant enterobacteriaceae infections. Results The factors associated with ertapenem-resistant enterobacteriaceae infections were prior exposure to carbapenems (adjusted OR 3.43; 95% IC 1.08-10.87) and prior exposure to cefepime (adjusted OR 6.46; 95% IC 1.08-38.38). Conclusion Prior exposure to antibiotics is the factor that best explains the ertapenem-resistant enterobacteriaceae infection in this population, highlighting the importance of antimicrobial stewardship programs in hospitals.",

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author = "Natalia Maldonado and Bibiana Castro and Indira Berrio and Miguel Manjarr{\'e}s and Carlos Robledo and Jaime Robledo",

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Ertapenem resistance in 2 tertiary-care hospitals: Microbiology, epidemiology, and risk factors. / Maldonado, Natalia; Castro, Bibiana; Berrio, Indira et al.
En: Enfermedades Infecciosas y Microbiologia Clinica, Vol. 35, N.º 8, 10.2017, p. 511-515.

Producción científica: Contribución a una revista › Artículo en revista científica indexada › revisión exhaustiva

TY - JOUR

T1 - Ertapenem resistance in 2 tertiary-care hospitals

T2 - Microbiology, epidemiology, and risk factors

AU - Maldonado, Natalia

AU - Castro, Bibiana

AU - Berrio, Indira

AU - Manjarrés, Miguel

AU - Robledo, Carlos

AU - Robledo, Jaime

PY - 2017/10

Y1 - 2017/10

N2 - Introduction Carbapenems resistance is a growing phenomenon and a threat to public health because of the reduced therapeutic options for resistant infections. Methods A retrospective case-control study was conducted in 2 tertiary-care hospitals in Medellín, Colombia. Fifty patients infected with ertapenem-resistant enterobacteriaceae were compared with a control group consisting of 100 patients with infections caused by ertapenem susceptible enterobacteriaceae. A multivariate logistic regression model was used to identify factors that best explain ertapenem-resistant enterobacteriaceae infections. Results The factors associated with ertapenem-resistant enterobacteriaceae infections were prior exposure to carbapenems (adjusted OR 3.43; 95% IC 1.08-10.87) and prior exposure to cefepime (adjusted OR 6.46; 95% IC 1.08-38.38). Conclusion Prior exposure to antibiotics is the factor that best explains the ertapenem-resistant enterobacteriaceae infection in this population, highlighting the importance of antimicrobial stewardship programs in hospitals.

AB - Introduction Carbapenems resistance is a growing phenomenon and a threat to public health because of the reduced therapeutic options for resistant infections. Methods A retrospective case-control study was conducted in 2 tertiary-care hospitals in Medellín, Colombia. Fifty patients infected with ertapenem-resistant enterobacteriaceae were compared with a control group consisting of 100 patients with infections caused by ertapenem susceptible enterobacteriaceae. A multivariate logistic regression model was used to identify factors that best explain ertapenem-resistant enterobacteriaceae infections. Results The factors associated with ertapenem-resistant enterobacteriaceae infections were prior exposure to carbapenems (adjusted OR 3.43; 95% IC 1.08-10.87) and prior exposure to cefepime (adjusted OR 6.46; 95% IC 1.08-38.38). Conclusion Prior exposure to antibiotics is the factor that best explains the ertapenem-resistant enterobacteriaceae infection in this population, highlighting the importance of antimicrobial stewardship programs in hospitals.

KW - Carbapenem resistance

KW - Carbapenems

KW - Enterobacteriaceae infections

KW - Risk factors

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VL - 35

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Ertapenem resistance in 2 tertiary-care hospitals: Microbiology, epidemiology, and risk factors

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